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13 Cards in this Set
- Front
- Back
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Aspirin |
Oral Anti-platelet drug (give in *low doses!!!!) MOA: Irreversible acetylation of COX1 Uses: MI, unstable angina, stroke, Kawasaki disease Contraindications: Asthma patients; *high doses should not be given because will form clot due to prostacyclin/PGE inhibition |
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Clopidogrel |
Oral- Anti-platelet drug MOA: Irreversible blockade of ADP receptors on platelets, which in turn inhibits binding of fibrinogen to glycoprotein 2b/3a on PLT surface Uses: When Aspirin is contraindicated e.g gastric ulcer patients |
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Abciximab |
IV- monoclonal Antibody - antiPLT drug MOA: Inhibits glycoprotein 2b/3a protein AE: bleeding, thrombocytopenia |
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Heparin |
IV/SC - Anticoagulant HMWH or LMWH; Vd=4L (stays in plasma) MOA: Accelerates Anti-thrombin III (neutralizes factors of the coagulation cascade; especially inhibits thrombin) LMWH is more selective on Factor Xa. Uses: Embolism, acute MI, unstable angina, pregnancy-safe aPTT monitors anticoag effect of heparin AE: HMWH thombocytopenia (low PLT count) |
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Protamine sulphate |
Reverses action of heparin by binding to heparin. |
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Warfarin/Coumadin |
Oral - anticoagulant -lipid soluble 1-3 days before effect (does not act immdiately like heparin does) Uses: Afib, flutter, prosthetic heart valves, embolism prevention, post MI preventative measures MOA: Vitamin K antagonist-inhibits vit K epoxide reductase inhibitor INR/PT testing to monitor effects AE: Gout, Protein C deficiency contraindication, fetal toxicity- DONT GIVE PREGNANT |
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Fresh Vitamin K reverses? |
Reverse warfarin effects |
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Dabigitran |
Oral MOA: DIRECT thrombin inhibition Uses: Heparin induced thrombocytopenia AE: Back pain (common); bleeding |
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Bivalirudin |
IV Analog of hirudin in leech saliva MOA: DIRECT thrombin inhibition Uses: Heparin induced thrombocytopenia AE: Back pain (common); bleeding |
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RivaroXaban |
Factor Xa inhibitor |
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Alteplase |
IV Recombinant tPA; Converts plasminogen --> plasmin (anticoagulant); Plasmin digests fibrin into FDP's. USES: 1. Stroke, 2. Pulmonary Embolism, 3. Acute MI (reduced mortality in MI) Severe AE: hemorrhages due to systemic lytic state. Cerebral hemorrhages. Note: loss of conscious intracranial hemorrhage and then they die!! inable to open 100% of occlusion in coronary artery, bleeding complications, inability to maintain good flow infarct after patency, contraindicated in aneurysms and hemorrhages. |
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Aminocaproic acid |
Anti-plasmin drug |
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Vitamin K, clotting factors |
Coagulants |
