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19 Cards in this Set
- Front
- Back
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protein C inactivates
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5 AND 8 A FACTORS OF COAGULATION : THUS RESULTING IN BLEEDING.
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factor 5 leiden mutation causes resistence to activated protein C which results in:
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more blood clotting.
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thrombomudilin activates
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protein C
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arterial thrombus
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consits of platelet rich clot
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venous thrombus
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rich in fibrin and decreased platelets than arterial clots.
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clopidogrel and
ticlopidine (both are irreversible) |
ADP receptors blockers: platelet aggregation inhibitors.
IRRIVERSIBLE |
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dipyridamol
cilostazol |
phospphodiestrase inhibitors.
promote vasodialtion and thus platelet inhibition. |
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abciximab(irreversible)
eptifibatide tirofiban |
blockers of platelet Gp IIb/IIIa receptors.
Inhibits platelet aggreagation. |
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misssing IIb/IIIa receptors on platelets
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glanzmann's thromblasthenia
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fondaparinix
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selective Factor Xa inhibitors: ANTICOAGULANTS
binds to antithrombin and induces a conformation change for it binding to factor 10a. |
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lepirudin
desirudin bivalirudin argatroban |
all are direct antithrobbin inhibitors thus promote bleeding(anticoagulants).
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heparin effect is due to its action on
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antithrombin III
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antithrombin inactivates
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thrombin, factors: 9, 10, 11 a hactors.'s
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low molecular weight heparin
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inhibit factor 10, but have less effcet on thrombin that UFH.
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enoxaparin
dalteparin tinzaparin |
are all LMWH
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protamine sulfate is antagonist to
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heparin
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danaparoid
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LMWH: antithrombin activity by inhibiting antithrombin III mediated inhibition of factor 10a.`
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warfarin
dicumarol |
coumarin anticoagulants (drug effect is not observed 8-12 hrs after adminstratin).
act by antagonising cofactor function of vit K(by inhibiting vit K epoxide) |
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cutaneous necrosis
hemmorrage crosses placenta thromboisi |
all are adversae effects of coumarin anticoagulants.
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