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7 Cards in this Set
- Front
- Back
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WARFARIN
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Vit K antagonist
Inhibits formation of γ-carboxy glutamyl residues Inhibits function of Vitamin K Epoxide Reductase Anti-coagulate with Heparin, then switch to Warfarin Prolonged PT and ↑ INR CONTRAINDI: PREGNANCY can lead to bleeding disorders |
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HEPARIN
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anticoagulant to prevent thrombus formation and pulmonary embolisms
Bleeding – can be reversed with protamine sulfate Hypersensitivity reaction: fever, chills, rash, urticaria, anaphylactic reaction. Anaphylactic reactions can also occur in patients with administration of protamine sulfate. Thrombocytopenia (HIT) Elevated LFTs (ALT & AST) Osteoporosis Pentasaccharide sequence necessary for binding to antithrombin III Given IV or SQ Short half life Doesn’t cross membrane- safe in pregnancy |
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THROMBIN (IIa) INHIBITORS:
LEPIRUDIN |
Polypeptide inhibits thrombin activity.
Used in case of HIT Leeches (hirudin) |
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THROMBIN (IIa) INHIBITORS:
BIVALIRUDIN |
Synthetic oligopeptide that inhibits thrombin
Occupies the catalytic site of thrombin and slows activity |
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THROMBIN (IIa) INHIBITORS:
ARGATROBAN |
Synthetic Thrombin Inhibitor
Indicated in HIT Metabolized by CYP |
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THROMBIN (IIa) INHIBITORS:
DANAPAROID |
Mixture of non-heparin GAGs
Inhibits factor Xa by antithrombin Does not elevate PT/PTT |
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THROMBIN (IIa) INHIBITORS:
DROTRECOGIN ALPHA |
similar to Protein C
Inactivates Factors Va and VIIIa |
