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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Enoxaparin
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prototype LMWH
Enzymatically treated UFH results in LMWH which has the same clinical outcomes and is easier to use |
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Fondaparinux
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Synthetic. MW 1500D. t1/2=17H, targets Xa.
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Heparin
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Biologic, MW 15000D, t1/2=1H,
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Approved tx: PE, DVT, thromboprophylaxis in hip/knee/ect surgery patients
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Heparin, LMWH, Fondaparinux
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Direct acting anticoagulants
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Directly target thrombin:
Lepiridin, Bivalirudin, Argatroban, Dabigatran (oral) |
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Aspirin (generic name)
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(acetylsalicylic acid) irreversible blocker of prostoglandin TxA2. Only NSAID that goes after platelet.
What is TxA2 and what is it's function? |
Thromboxane A2 increases platelet aggregation & vasoconstricts
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Clopidogrel use
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used in Asprin sensitive patients. Has an antiplatelet effect by inhibiting platelet ADP receptors
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Adciximab
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GP 2B & 3A antagonist. This is an antibody that targets above receptors found in high concentrations on platelet surface. Blocks final common platelet aggregation pathway
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Thrombolytic drug Names
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Streptokinase
& Tissue plasminogen activator (tPA) |
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Streptokinase
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thrombolytic that dissolves clots. Forms complex w/ plasminogen resulting in conformational change that results in cleavage of circulating plasminogen to free plasmin
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tissue plasminogen activator (tPA)
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greater activity against plasmniogen bound to fibrin. At high doses may induce lytic state = increase rate of bleeding
Uses t-PA |
acute ischemic stroke (<3H onset)
acute STEMI (<12H) |
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Use of thrombolytics
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Not routinely used in management of venous thrombosis or pulmonary embolism
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