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8 Cards in this Set
- Front
- Back
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What is myasthenia Gravis? |
Autoimmune destruction of the Ach receptors at the NMJ Causes the eye to droop, can be treated with an increase in the concentration of Ach at the NMJ |
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What is the effect on autonomic synapses? |
enhanced parasympathetic response i.e. increased glandular secretions, reduced heart rate and blood pressure, bronchoconstriction |
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What is the effect on the NMJ? |
Therapeutic doses: increases the force of contraction of the muscle Toxic dose: reduced force of contraction |
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What is the effect on the CNS? |
Therapeutic doses: mild stimulation resulting in convulsion Toxic doses: depress the CNS, respiratory depression |
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Edrophonium |
- short acting reversible anticholinesterase - not clinically used - Used for the diagnosis of Myasthenia Gravis - Gives very short relief of symptoms |
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Neostigmine |
- Clinically used for the treatment of Myasthenia gravis - increases the concentration of Ach at the NMJ which results in muscular contraction - medium acting reversible anticholinesterase - hydrolysis of the enzyme is slow resulting in long lasting effects |
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Sugammadex |
- Clinically used for the treatment of Myasthenia gravis - increases the concentration of Ach at the NMJ which results in muscular contraction - medium acting reversible anticholinesterase - hydrolysis of the enzyme is slow resulting in long lasting effects |
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Pyridostigmine |
- Clinically used for the treatment of Myasthenia gravis - increases the concentration of Ach at the NMJ which results in muscular contraction - medium acting reversible anticholinesterase - hydrolysis of the enzyme is slow resulting in long lasting effects |
