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13 Cards in this Set

  • Front
  • Back
Enzyme class that cholinesterases belong to
serine hydrolases
What's the active site for cholinesterase
critical serine
What are the two plasma cholinesterases?
butyrylcholinesterase and pseudocholinesterase

These are made from seperate genese and are differentiated by their ability to hydrolyze 'butyrylcholine'
Name the reversible AChe-I's.
physostigmine, edrophonium, neostigmine, pyrostigmine
What's the secret of reversible AChe-I's function?
They form carbamyl complexes with cholinesterase with much longer half life than acyl enzymes formed when ACh is the substrate.
drugs used in dx and tx of myasthenia gravis?
edrophonium, neostigmine, pyridostigmine
How are the non-depolarizing NMJ blockade reversed?
with edrophonium and neostigmine
Drugs used for Alzheimer's dz?
donepezil, rivastigmine, glantamine
What's speical about AChe-I donepezil, glantamine
They are metabolized by Cyt P450 enzymes and not the plasma cholinesterases.

Galantamine can also allosterically promte nicotinic recepter function.
How to reverse GI and bladder atony?
give localized injection of neostigmine
Physostigmine, echothiopate, and demecarium are useful in what condition? How?
glaucoma, reduce intraocular pressure by disabling iris sphincter
OD of cholinergic blockers (atropine, scopolamine can be treated how?
How else is physostigmine useful for military purpose?
prophylaxis for soman, an irreversible nerve agent