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13 Cards in this Set
- Front
- Back
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Enzyme class that cholinesterases belong to
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serine hydrolases
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What's the active site for cholinesterase
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critical serine
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What are the two plasma cholinesterases?
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butyrylcholinesterase and pseudocholinesterase
These are made from seperate genese and are differentiated by their ability to hydrolyze 'butyrylcholine' |
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Name the reversible AChe-I's.
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physostigmine, edrophonium, neostigmine, pyrostigmine
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What's the secret of reversible AChe-I's function?
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They form carbamyl complexes with cholinesterase with much longer half life than acyl enzymes formed when ACh is the substrate.
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drugs used in dx and tx of myasthenia gravis?
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edrophonium, neostigmine, pyridostigmine
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How are the non-depolarizing NMJ blockade reversed?
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with edrophonium and neostigmine
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Drugs used for Alzheimer's dz?
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donepezil, rivastigmine, glantamine
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What's speical about AChe-I donepezil, glantamine
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They are metabolized by Cyt P450 enzymes and not the plasma cholinesterases.
Galantamine can also allosterically promte nicotinic recepter function. |
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How to reverse GI and bladder atony?
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give localized injection of neostigmine
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Physostigmine, echothiopate, and demecarium are useful in what condition? How?
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glaucoma, reduce intraocular pressure by disabling iris sphincter
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OD of cholinergic blockers (atropine, scopolamine can be treated how?
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physostigmine
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How else is physostigmine useful for military purpose?
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prophylaxis for soman, an irreversible nerve agent
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