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10 Cards in this Set
- Front
- Back
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AChE vs. plama cholinesterases
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AChE does not hydrolyze butyrulcholine, while butyrylcholinesterase and psuedocholinesterase does.
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reversible AChE-I
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physostigmine, edrophonium, neostigmine, pyridostigmine, donepezil, rivastigmine, galantamine... block by forming carbamyl complexes
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reversible AChE-I used for
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(Tensilon test)dx and tx of myasthenia gravis.../ reverse non-depolarizing competitive neuromuscular junction blockage, alzheimer's dz (donepezil, rivastigmine, galantamine), glaucoma, atropine OD with physostigmine
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What's special about donepezil and galantamine
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metabolized by Cyt P450, and not plasma cholinesterases
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Name organophosphates
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VX, soman (GD), Sarin (GB), Tabun (GA), echothiophate (used in glaucoma), parathion, malathion
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2PAM is not effective against it.
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Soman (GD). pyridostigmine, physostigmine may be used as prophylaxis.
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VX
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good skin penetrance
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treatment of convulsion
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diazepam
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soman poisoning
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used pyridostigmine or physostigmine as prophylaxis
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BZ, antiriot agent,
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An AChE-I, use physostigmine
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