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10 Cards in this Set

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AChE vs. plama cholinesterases
AChE does not hydrolyze butyrulcholine, while butyrylcholinesterase and psuedocholinesterase does.
reversible AChE-I
physostigmine, edrophonium, neostigmine, pyridostigmine, donepezil, rivastigmine, galantamine... block by forming carbamyl complexes
reversible AChE-I used for
(Tensilon test)dx and tx of myasthenia gravis.../ reverse non-depolarizing competitive neuromuscular junction blockage, alzheimer's dz (donepezil, rivastigmine, galantamine), glaucoma, atropine OD with physostigmine
What's special about donepezil and galantamine
metabolized by Cyt P450, and not plasma cholinesterases
Name organophosphates
VX, soman (GD), Sarin (GB), Tabun (GA), echothiophate (used in glaucoma), parathion, malathion
2PAM is not effective against it.
Soman (GD). pyridostigmine, physostigmine may be used as prophylaxis.
VX
good skin penetrance
treatment of convulsion
diazepam
soman poisoning
used pyridostigmine or physostigmine as prophylaxis
BZ, antiriot agent,
An AChE-I, use physostigmine