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16 Cards in this Set
- Front
- Back
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Neostigmine
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*Reversible
*Cholinergic agonist *Direct nicotinic agonist |
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Physostigmine
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*Reversible
*Lipid soluble (can get into CNS) |
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Pyridostigmine
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*Reversible
*Little CNS activity, more selective for CHE is SKM |
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Ambedonium
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*Reversible
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Edrophonium
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*Reversible
*Short acting |
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Demecarium
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*Reversible
*long acting |
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Donepezil
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*Reversible
*Enters CNS *Used for Addison's disease |
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Galantamine
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*Reversible
*Enter CNS *Used for Addison's disease |
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Rivastigmine
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*Reversible
*Enters CNS *Used for Addison's Disease |
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Tacrine
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*Reversible
*Enters CNS *Used for Addison's Disease |
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Diisopropyl Phosphofluoridate (DFP)
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*Irreversible
*Volatile, Very lipid soluble *Can get into CNS |
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Parathion
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*Irreversible
*Pro Drug *Insecticide *hepatic metabolism to paraoxan |
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Malathion
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*Irreversible
*Insecticide *Active Metabolite |
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Echothiophate
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*Irreversible
*Poor lipid solubility *Low toxicity *Positively charged, low volatility |
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Irreversible Process
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Is a two step process. It is reversible until step 2.
1. Phosphorylate active site 2.Stability of phosphorylated enzyme enhanced by loss of an alkoxy group = aging. |
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Insecticide metabolism
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Rapidly detoxified in vertebrates, not in insects.
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