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44 Cards in this Set
- Front
- Back
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Mechlorethamine
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Alkylate DNA bases = breakage
spontaneously converts to reactive cytoxic product |
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Cyclophosphamide
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Alkylate DNA = breakage
Prodrug - P450 Inhibit DNA synthesis |
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Melphalan
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Alkylate DNA bases = breakage
Inhibit DNA synthesis |
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Busulfan
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Alkylate DNA bases
Inhibits DNA synthesis |
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Procarbazine
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Alkylate DNA bases
forms H2O2 = FRs Inhibit DNA, RNA, protein synthesis |
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Carmustine
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Alkylate DNA = inhibit
crosses BBB (lipid soluble) |
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Lomustine
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Alkylate DNA = inhibit
crosses BBB (lipid soluble) |
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Streptozocin
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Alkylate DNA = inhibit
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Cisplatin
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Binds DNA & inhibits synthesis/fxn
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Carboplatin
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Binds DNA & inhibits synthesis/fxn
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Oxaliplatin
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Binds DNA & inhibits synthesis/fxn
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Methotrexate (MTX)
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Inhibits dihydrofolate reductase
decrease DNA, RNA, protein synth |
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Leucovorin
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Antidote for MTX overdose
form of folic acid = folinic acid bypasses the DHF reductase step |
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Pemetrexed
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Inhibits Thymidylate synthase
converted to polyglutamates inside cell |
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6-MP
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Inhibit Purine synthesis
Prodrug- HGPRTases X-rxn with Allopurinol (xanthine oxidase) |
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Fludarabine Phosphate
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Inhibit DNA synthesis/repair
converted to active nucleotide in cell |
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Cladribine
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Decrease DNA synthesis/repair
incorp. into DNA |
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5-Fluorouracil (5-FU)
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Inhibit Thymidylate synthase
Incorp'd into DNA/RNA |
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Cytarabine
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Pyrimidine antimetabolite
Inhibit DNA polymerase (S phase) |
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Gemcitabine
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Inhibit Ribonuleotide reductase
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Dactinomycin
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binds DNA & interferes with RNA synthesis
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Doxorubicin
Daunorubicin |
Inhibits topoisomerase II
FR formation MB disruption intercalated into DNA |
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Bleomycin
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Binds DNA = strand breaks
mix of glycoproteins that generate FRs thru Fe complexes |
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Mitomycin
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Metabolized by liver to form alkylating agent
cross links DNA |
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Vincristine
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mitotic spindle inhibitor
prevents assembly of tubulin dimers into microtubules |
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Vinblastine
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mitotic spindle inhibitor
prevents assembly of tubulin dimers into microtubules |
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Paclitaxel
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promotes formation of microtubules
inhibits mitosis |
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Etoposide
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Inhibit topoisomerase II
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Topotecan
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Inhibit topoisomerase I
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Irinotecan
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inhibit topoisomerase I
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Asparaginase
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Depletes asparagine = dec protein synthesis
catalyzes hydrolysis of L-asparagine to aspartic acid/NH3 |
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Imatinib
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inhibits Bcr-Abl tyrosine kinase
induce apoptosis |
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Cetuximab
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Binds to extracellular domain of epidermal growth factor receptor
(EGFR) Monoclonal Ab Inhibits downstream signaling |
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Getfitinib
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inhibits tyrosine kinase domain of EGFR
inhibit receptor signaling |
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Erlotinib
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inhibits tyrosine kinase domain of EGFR
inhibit receptor signaling |
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Bevacizumab
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Binds VEGF & prevents it from interacting w/ its receptor
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Sorafenib
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inhibit multiple receptor tyrosine kinases - VEGF, PDGF
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Sunitinib
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inhibit multiple receptor tyrosine kinases - VEGF, PDGF
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All-trans retinoic acid
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Induces differentiations to cells that can't proliferate
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Arsenic Trioxide
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Induce differentiation
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Bortezomib
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proteasome inhibitor
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Hydroxyurea
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Inhibits ribonucleotide reductase
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Rituximab
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CD20 monoclonal Ab
B-cell surface protein |
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Trastuzumab
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HER-2/neu monoclonal Ab
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