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15 Cards in this Set

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was the best single agent for Breast Cancer <>widely used as anticancer agents against sarcomas, carcinomas(including breast , bladder, gastric and lungs), ALL and high grade lymphomas including Hodgkin's (part of ABVD regimen: Adriamycin, Bleomycin, Vinblastine, Dacarbazine)
DOXORUBICIN (Adriamycin)
stomach and breast (salvage regimen), only in combination with other drugs
MITOMYCIN C
copper chelating glycopeptide, G2 cell cycle specific, bind to DNA and Fe ions leading to Oxygen radical formation, breaking DNA, cell arrested in G2
BLEOMYCIN from mold
cardiac toxicity
DOXORUBICIN (ADRIAMYCIN
pulmonary toxicity: pneumonitis can develop into irreversible and fatal pulmonary fibrosis (monitor with serial pulmonary fct tests), symptomatic Tx with Oxygen is CONTRAindicated because it can worsen, , is unique in that it rarely cause myelosuppression, fever and chills (Tx with Tylenol), Anaphylaxis (give test dose), cutaneous toxicity: hypertrophic skin,
BLEOMYCIN from mold
intercalate between G and C base pairs, therefore interfer with Topo II and RNA polymerase
actinomycin D (DACTINOMYCIN)
MITOMYCIN C
extensive HEPATIC metabolism, excreted in bile, must modify dose if hepatic disease present
DOXORUBICIN (Adriamycin)
rarely used, if use, to tx Wilms' tumor (renal tumor of early childhood) in concert with Vincristine and surgery, testicular carcinoma<> also given with METHOTREXATE for gestational Choriocarcinoma
actinomycin D (DACTINOMYCIN)
MITHRAMYCIN
less commonly used, when used, treat testicular carcinoma and hypercalcemia
important to determine lifetime exposure to avoid cardiotoxicity (total dose over 500mg/m2)
(ANTHRACYCLINE from mold)
DOXORUBICIN (Adriamycin)
Doxorubicin turns urine red, cardiotoxicity because the heart has low [SOD] (superoxide dismutase) making it more susceptible to superoxide radicals, cardiotoxicity is IRREVERSIBLE AND CUMULATIVE so lifetime dose must not exceed 500mg/m2, bone marrow suppression, stomatitis, GI disturbances, severe Alopecia, vesicant
copper chelating glycopeptide, G2 cell cycle specific, bind to DNA and Fe ions leading to Oxygen radical formation, breaking DNA, cell arrested in G2
BLEOMYCIN from mold
S and G2
DOXORUBICIN (Adriamycin)
G2
BLEOMYCIN from mold
Go
actinomycin D (DACTINOMYCIN)
MITOMYCIN C
MITHRAMYCIN
Additional ADR: Leukemogenic
DAUNORUBICIN