Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
was the best single agent for Breast Cancer <>widely used as anticancer agents against sarcomas, carcinomas(including breast , bladder, gastric and lungs), ALL and high grade lymphomas including Hodgkin's (part of ABVD regimen: Adriamycin, Bleomycin, Vinblastine, Dacarbazine)
|
DOXORUBICIN (Adriamycin)
|
|
|
stomach and breast (salvage regimen), only in combination with other drugs
|
MITOMYCIN C
|
|
|
copper chelating glycopeptide, G2 cell cycle specific, bind to DNA and Fe ions leading to Oxygen radical formation, breaking DNA, cell arrested in G2
|
BLEOMYCIN from mold
|
|
|
cardiac toxicity
|
DOXORUBICIN (ADRIAMYCIN
|
|
|
pulmonary toxicity: pneumonitis can develop into irreversible and fatal pulmonary fibrosis (monitor with serial pulmonary fct tests), symptomatic Tx with Oxygen is CONTRAindicated because it can worsen, , is unique in that it rarely cause myelosuppression, fever and chills (Tx with Tylenol), Anaphylaxis (give test dose), cutaneous toxicity: hypertrophic skin,
|
BLEOMYCIN from mold
|
|
|
intercalate between G and C base pairs, therefore interfer with Topo II and RNA polymerase
|
actinomycin D (DACTINOMYCIN)
MITOMYCIN C |
|
|
extensive HEPATIC metabolism, excreted in bile, must modify dose if hepatic disease present
|
DOXORUBICIN (Adriamycin)
|
|
|
rarely used, if use, to tx Wilms' tumor (renal tumor of early childhood) in concert with Vincristine and surgery, testicular carcinoma<> also given with METHOTREXATE for gestational Choriocarcinoma
|
actinomycin D (DACTINOMYCIN)
|
|
|
MITHRAMYCIN
|
less commonly used, when used, treat testicular carcinoma and hypercalcemia
|
|
|
important to determine lifetime exposure to avoid cardiotoxicity (total dose over 500mg/m2)
|
(ANTHRACYCLINE from mold)
DOXORUBICIN (Adriamycin) Doxorubicin turns urine red, cardiotoxicity because the heart has low [SOD] (superoxide dismutase) making it more susceptible to superoxide radicals, cardiotoxicity is IRREVERSIBLE AND CUMULATIVE so lifetime dose must not exceed 500mg/m2, bone marrow suppression, stomatitis, GI disturbances, severe Alopecia, vesicant |
|
|
copper chelating glycopeptide, G2 cell cycle specific, bind to DNA and Fe ions leading to Oxygen radical formation, breaking DNA, cell arrested in G2
|
BLEOMYCIN from mold
|
|
|
S and G2
|
DOXORUBICIN (Adriamycin)
|
|
|
G2
|
BLEOMYCIN from mold
|
|
|
Go
|
actinomycin D (DACTINOMYCIN)
MITOMYCIN C MITHRAMYCIN |
|
|
Additional ADR: Leukemogenic
|
DAUNORUBICIN
|
