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30 Cards in this Set

  • Front
  • Back
CCS
1. Antimetabolites
2. Antitumor Agents
3. Epipodophyllotxins
4. Taxanes
5. Vinca Alkaloids
CCNS
1. Alkylating Agents
2. Anthracyclines
3. Antitumor antibiotics
4. Camptothecins
5. Platinum Analogs
Cyclophosphamine
alkylating agent
Methrotrexate
Antimetabolite
Rescue Therapy
Leucovorin decreases toxicity of Methrotrexate to normal cells
Mercaptopurine (6-MP)
-Antimetabolite
-bioactivated
-interacts with allopurinol by binding to enzyme (xantine oxidase) that is needed to detoxify the body from 6-M
Fluorouracil (5-FU)
-Antimetabolte
-Not administered orally
-Both DNA and RNA mediated events
Vinca Alkaloids
-vinblastine, vincristine, vinorelbrine
-depolarization of microtubules when bind to tubulin
-mitotic arrest
Toxicity in Vinblastine
bone marrow depression
Toxicity in Vincristine
neurotoxicity
Epipodophyllotoxins
-Etoposide and Teniposide
-inhibits Topoisomerase II enzyme
Camptothecins
-Topotecan and Irinotecan
-inhibits activity of topoisomerase I
Taxanes
-Paclitaxal and Docetaxal
-mitotic spindle posisons through high-affinity binding to microtubules with enhancement of tubulin polymerization
-inhibition of mitosis and cell division
Anthracyclines
-Daunorubin and Doxorubicin
-high affinity binding to DNA through intercalation
Toxicities of Anthracyclines
-Myelosupression
-Cardiotoxicity
Mitomycin
-Mitomycin C
-CCNS alkylating agent
-cross-link DNA; bifuncational alkylating agent
Bleomycin
-CCS
-Binds to DNA and Iron, forms a complex that is oxidized leading to free radicals and damages DNA
Toxicity of Bleomycin
pulmonary toxicity
Tamoxifen
SERM
-estrogen-agonist: bone and uterus
-anti-estrogen: breast tissue
Raloxifene
SERM
-anti-estrogen: uterus
Fulvestrant
SERD
-pure anti-estrogens
Flutamide and Bicalutamide
anti-androgen-bind to androgen sensitive tumors and block androgen effects
Leuprolide and Goserelin
GnRH agonists
-decrease levels of testosterone drastically
-prostate cancer
Aminoglutethimide
-aromatase inhibitor
-will inhibit glucocorticoids (adrenal insufficiency)
Anastozole
more effective, nonsteriodal inhibitor (selective)
-Aromatase inhibitor
-does not cause adrenal insufficiency
-Letrazole is a derivative
Letrazole
derivative of Anastozole
Exemestane
-Steroidal hormonal agent
-aromatase inhibitor
-No-cross resistance
Protein Tyrosine Kinase Inhibitor
-Imatinib, Gefinib, Erlotinib
Imatinib
treats leukemia (CML, CMML)
Trastuzumab
-Herceptin
-first monoclonal antibody
-treated in breats cancer cases causes overexpression of EGF receptor (HERZ/neu)