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30 Cards in this Set
- Front
- Back
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CCS
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1. Antimetabolites
2. Antitumor Agents 3. Epipodophyllotxins 4. Taxanes 5. Vinca Alkaloids |
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CCNS
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1. Alkylating Agents
2. Anthracyclines 3. Antitumor antibiotics 4. Camptothecins 5. Platinum Analogs |
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Cyclophosphamine
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alkylating agent
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Methrotrexate
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Antimetabolite
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Rescue Therapy
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Leucovorin decreases toxicity of Methrotrexate to normal cells
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Mercaptopurine (6-MP)
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-Antimetabolite
-bioactivated -interacts with allopurinol by binding to enzyme (xantine oxidase) that is needed to detoxify the body from 6-M |
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Fluorouracil (5-FU)
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-Antimetabolte
-Not administered orally -Both DNA and RNA mediated events |
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Vinca Alkaloids
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-vinblastine, vincristine, vinorelbrine
-depolarization of microtubules when bind to tubulin -mitotic arrest |
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Toxicity in Vinblastine
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bone marrow depression
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Toxicity in Vincristine
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neurotoxicity
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Epipodophyllotoxins
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-Etoposide and Teniposide
-inhibits Topoisomerase II enzyme |
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Camptothecins
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-Topotecan and Irinotecan
-inhibits activity of topoisomerase I |
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Taxanes
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-Paclitaxal and Docetaxal
-mitotic spindle posisons through high-affinity binding to microtubules with enhancement of tubulin polymerization -inhibition of mitosis and cell division |
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Anthracyclines
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-Daunorubin and Doxorubicin
-high affinity binding to DNA through intercalation |
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Toxicities of Anthracyclines
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-Myelosupression
-Cardiotoxicity |
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Mitomycin
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-Mitomycin C
-CCNS alkylating agent -cross-link DNA; bifuncational alkylating agent |
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Bleomycin
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-CCS
-Binds to DNA and Iron, forms a complex that is oxidized leading to free radicals and damages DNA |
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Toxicity of Bleomycin
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pulmonary toxicity
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Tamoxifen
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SERM
-estrogen-agonist: bone and uterus -anti-estrogen: breast tissue |
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Raloxifene
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SERM
-anti-estrogen: uterus |
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Fulvestrant
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SERD
-pure anti-estrogens |
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Flutamide and Bicalutamide
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anti-androgen-bind to androgen sensitive tumors and block androgen effects
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Leuprolide and Goserelin
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GnRH agonists
-decrease levels of testosterone drastically -prostate cancer |
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Aminoglutethimide
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-aromatase inhibitor
-will inhibit glucocorticoids (adrenal insufficiency) |
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Anastozole
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more effective, nonsteriodal inhibitor (selective)
-Aromatase inhibitor -does not cause adrenal insufficiency -Letrazole is a derivative |
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Letrazole
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derivative of Anastozole
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Exemestane
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-Steroidal hormonal agent
-aromatase inhibitor -No-cross resistance |
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Protein Tyrosine Kinase Inhibitor
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-Imatinib, Gefinib, Erlotinib
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Imatinib
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treats leukemia (CML, CMML)
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Trastuzumab
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-Herceptin
-first monoclonal antibody -treated in breats cancer cases causes overexpression of EGF receptor (HERZ/neu) |
