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5 Cards in this Set
- Front
- Back
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Glycopeptides/polypeptides: Common Examples
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Glycopeptides: Vancomycin, Colistin, Daptomycin
Polypeptides: Bacitracin |
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Mechanism of Action
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Glycopeptides: Interfere with formation of bridges between peptidoglycan chains. Works a step before beta-lactams
Bacitracin: Prevents transport of peptidoglycan precursors across membrane. Used topically only. |
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Typical Use
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- Excellent gram positive coverage (staph and strep)
- Used for MRSA and other beta lactam resistant gram positives - Inferior to oxacillin against MRSA |
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Side Effects
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- hypersensitivity
- must be given slowly. Can produce Red Man Syndrome: rash on face, neck, trunk |
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Resistance Mechanisms
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- Alteration of the terminus of the pentapeptide side chains on peptidoglycan, alters drug binding site
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