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35 Cards in this Set
- Front
- Back
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Mechanism of action of sulfonamides
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They act by inhibiting folic acid synthetase which converts PABA to Folic Acid
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Mechanism of action of Cotrimoxazole
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Trimethoprim inhibits dihydrofolate reducatse enzyme which converts dihydrofolate into tetrahydrofolate. It has got synergisitic action with sulfamethoxazole.
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Mechanism of action of Quinolones
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Act by interfering with the synthesis of DNA
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Mechanism of action of Penicilin
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Act by interfering with the cell wall synthesis of bacteria
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Mechanism action of Cephalosporins
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They are bactericidal. They act by inhibiting cell wall synthesis
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Mechanism of action of Macrolides
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They act by inhibiting protein synthesis and also by blocking ribosomal activity.
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Mechanism of action of Aminoglycosides
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They block the RNA-ribosome combination and also inhibits the enzymes involved in Kreb's Cycle.
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Mechanism of action of Tetracyclines
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They are bacteriostatic. They act by inhibitng enzyme synthesis, protein synthesis and ribosomal activity.
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Examples of Sulfonamides
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All that start with sulfa- prefix
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Examples of Quinolones
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Nalidixic Acid
All the others which end in -floxacins |
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Examples of Penicilin
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All those which end in -cillin.
Clindamycin Linomycin Vancomycin |
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Examples of 1st generation cephalosporins
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Cephalexin
Cephadroxyl Cephadrine Cephazolin Cephalothin Cepharin |
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Examples of 2nd generation cephalosporins
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Cefuroxime
Cefaclor Cefamandone Cefoxitin Cefonicid Ceforanide |
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Examples of 3rd generation cephalosporins
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Cefetoxime
Ceftriaxone Ceftizoxime Ceftazidime Cefperazone Cefixime |
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Examples of 4th generation cephalosporins
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Cefepime
Cefpodoxime |
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Examples of Macrolides
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Erythromycin
Roxithromycin Azithromycin Clarithromycin Spiramycin |
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Examples of Aminoglycosides
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Kanamycin
Gentamycin Tobramycin Amikacin Neomycin |
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Use of Sulfonamides
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UTI
Chancroid Trachoma Ulcerative Colitis Toxoplasma B. dysentery |
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Use of Quinolones
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Allergic Reactions
CNS Manifestation Hallucination Nephritis Arrythmias |
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Use of Penicillin
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Streptococcus
Pneumococcus Meningococcus Gonococcal infections Syphilis Tetanus Gas gangrene Actinomycosis Plague |
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Others uses of Penicillin
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Also used as prophylaxis in rheumatic fever.
Pelvic Infection Lymphoedema |
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Ampicillin/Amoxycyllin
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Respiratory Infections
Cutaneous Infections Meningitis Endocarditis |
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Methicillin
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Penicillin resistant Staph Infection.
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Cloxacillin
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Penicillin resistant Staph Infection.
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Carbenicillin
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Septicemia
UTI mainly due to Pseudomonas and Proteus |
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Use of Piperacillin
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Active against Pseudomonas
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Imipenem/Carbapenem/Meropenem
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Septicemia
Pseudomonas Klebsiella Proteus |
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Cephalosporins
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Useful in most of the infections
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Macrolides
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Respiratory Infection
Skin infections |
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Streptomycin
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TB
Plague Chancroid Granuloma Inguinale Brucellosis RI Gut sterilisation during large bowel preparation |
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Gentamycin
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Antipseudomonal Drug
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Tobramycin
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More effective against pseudomonas than gentamycin
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Neomycin
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Mainly used in hepatic Failure and gut sterilisation
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Tetracyclines
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Plague
Cholera STI |
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Chloramphenicol
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Typhoid Fever
Meningitis Plague |
