Antibiotics (Pharm) Intro

Front 1

What is Chemotherapy?

Back 1

The use of pure chemicals which have specific antagonistic effects on the infective organism without harming the host

Front 2

What is an antibiotic?

Back 2

Substance produced by a microorganism to kill or inhibit the growth of microorganisms

Front 3

What is an antibacterial?

Back 3

Synthetic substance that inhibits or kills microorganism

Front 4

What is an antimibrobial?

Back 4

Any substance of natural, semisynthetic or synthetic origin that kills or inhibits the growth of a microorganism but causes little or no host damage

Front 5

What do narrow spectrum antibiotics act on?
What do broad spectrum ABs act on?
Which are more difficult to treat?

Back 5

On only G+ or G- (usually G+)
Both G+ and G-
G-

Front 6

What bacteria is most likely in a cat abscess? A dog?

Back 6

Pasturella (tx w/ Clavimoxx)

Staph

Front 7

What may a false positive mean in antimicrobial therapy?

Back 7

That the AB my work in vitro, but may not in vivo

it may not be able to get to the site of the infection

Front 8

What may a false negative mean in antimicrobial therapy?

Back 8

The AB does not work in vitro, but may in vivo,

it may be able to concentrate at site of infection

Front 9

T/F most infections are intracellular.

Back 9

False

extracellular

Front 10

What is a concentration dependent killing antibiotic?
Is dosing more effective frequently or infrequently?

Back 10

One that is more effective at a concentration high above the MIC

Dose at less frequent intervals

Front 11

Which three groups of bacteria inhibit cell wall synthesis?

Back 11

Beta Lactam, Bactracin, Vancomycin

Front 12

Which group of bacteria inhibit cell membrane function?

Back 12

Polymyxins

Front 13

Which five groups of antibiotics inhibit protein synthesis?

Back 13

Aminoglycosides, Tetracyclines, Amphenicols, Macrolides, Lincosamides

Front 14

Which two groups of bacteria interfere with bacterial metabolism?

Back 14

Sulfonamides, Diaminopyrimidines

Front 15

Which four groups of ABs inhibit nucleic acid synthesis?

Back 15

Fluoroquinolones, Rifampin, Metronidazole, Nitrofurans

Front 16

What is the best way to determine if there is an infection present?

Back 16

culture

Front 17

What are other causes of what may seem like infections?

Back 17

Neoplasia, viral response, foreign body

Front 18

What is the difference between first, second and third line antibiotics?

Back 18

First line is used first, the third are saved for very resistant bacterial like Pseudomonas, staph, and tough enterics

Front 19

First line ABs kill what type of bacteria? Second line?

Back 19

G+ aerobes and anaerobes

G+ G- aerobes

Front 20

What is a time dependent killing antibiotic? Is dosing more effective frequently or infrequently?

Back 20

One that is more effective for a longer time slightly above the MIC

Dose at more frequent intervals