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20 Cards in this Set

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What is Chemotherapy?
The use of pure chemicals which have specific antagonistic effects on the infective organism without harming the host
What is an antibiotic?
Substance produced by a microorganism to kill or inhibit the growth of microorganisms
What is an antibacterial?
Synthetic substance that inhibits or kills microorganism
What is an antimibrobial?
Any substance of natural, semisynthetic or synthetic origin that kills or inhibits the growth of a microorganism but causes little or no host damage
What do narrow spectrum antibiotics act on?
What do broad spectrum ABs act on?
Which are more difficult to treat?
On only G+ or G- (usually G+)
Both G+ and G-
G-
What bacteria is most likely in a cat abscess? A dog?
Pasturella (tx w/ Clavimoxx)

Staph
What may a false positive mean in antimicrobial therapy?
That the AB my work in vitro, but may not in vivo

it may not be able to get to the site of the infection
What may a false negative mean in antimicrobial therapy?
The AB does not work in vitro, but may in vivo,

it may be able to concentrate at site of infection
T/F most infections are intracellular.
False

extracellular
What is a concentration dependent killing antibiotic?
Is dosing more effective frequently or infrequently?
One that is more effective at a concentration high above the MIC

Dose at less frequent intervals
Which three groups of bacteria inhibit cell wall synthesis?
Beta Lactam, Bactracin, Vancomycin
Which group of bacteria inhibit cell membrane function?
Polymyxins
Which five groups of antibiotics inhibit protein synthesis?
Aminoglycosides, Tetracyclines, Amphenicols, Macrolides, Lincosamides
Which two groups of bacteria interfere with bacterial metabolism?
Sulfonamides, Diaminopyrimidines
Which four groups of ABs inhibit nucleic acid synthesis?
Fluoroquinolones, Rifampin, Metronidazole, Nitrofurans
What is the best way to determine if there is an infection present?
culture
What are other causes of what may seem like infections?
Neoplasia, viral response, foreign body
What is the difference between first, second and third line antibiotics?
First line is used first, the third are saved for very resistant bacterial like Pseudomonas, staph, and tough enterics
First line ABs kill what type of bacteria? Second line?
G+ aerobes and anaerobes

G+ G- aerobes
What is a time dependent killing antibiotic? Is dosing more effective frequently or infrequently?
One that is more effective for a longer time slightly above the MIC

Dose at more frequent intervals