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23 Cards in this Set
- Front
- Back
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first penicillin available, and is bactericidal to mostly gram + and some gram -
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Penicillin G
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group of penicillins that are highly resistant to inactivation by ß-lactamases, narrow spectrum, and highly effective against staphylococcus infections
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Penicillinase-resistant penicillins
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penicillins that have useful activity against gram -, such as amoxicillin
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aminopenicillins
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first penicillin available, and is bactericidal to mostly gram + and some gram -
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Penicillin G
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group of penicillins that are highly resistant to inactivation by ß-lactamases, narrow spectrum, and highly effective against staphylococcus infections
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Penicillinase-resistant penicillins
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penicillins that have useful activity against gram -, such as amoxicillin
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aminopenicillins
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Penicillin
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inhibits cell wall synthesis (binds to PBP's) lysis and cell death
Bactericidal Mostly narrow |
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Cephalosporins
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disrupt cell wall synthesis, lysis and cell death
bactericidal broad |
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Carbapenems
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disrupt cell wall, lysis and death
bactericidal broad |
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Vancomycin
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inhibits cell wall synthesis
bactericidal narrow |
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Tetracyclines
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suppress growth by inhibiting protein sythesis (binds to 30S ribosomal subunit)
bacteriostatic broad |
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Macrolides
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inhibit protein synthsis (binds to 50S ribosomal subunit)
bacteriostatic (can be cidal against susceptible organisms) broad spectrum |
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which 2 antibiotics should not be mixed in IV solution?
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Aminoglycosides and Penicillins
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Clindamycin
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inhibits protein synthesis (binds to 50S ribosomal subunit)
bacteriostatic broad spectrum |
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Linezolid
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inhibits protein synthesis (binds to 23S portion of 50S r.s)
bacteriostatic |
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Aminoglycosides
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Inhibits protein synthesis (binds to 30S rs)
bactericidal broad |
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Sulfonamides
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suppress bacterial growth by inhibiting synthesis of folic acid (required to make DNA and RNA)
bacteriostatic broad |
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Fluoroquinolones
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inhibit bacterial DNA synthesis (prevent unwinding?)
bactericidal broad |
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Metronidazole (Flagal)
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lethal to anaerobes only, inhibits DNA synthesis
bactericidal narrow |
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Daptomycin
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inserts self into cell membrane and allows efflux of K+ out of cell, inhibits DNA synthesis
bactericidal narrow? |
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Rifampin
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inhibits RNA synthesis
bactericidal broad |
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Amphotericin B
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binds to fungal cell membrane, increases permeability, leaks cations
may be fungicidal or fungistatic |
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Azoles
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inhibits ergosterol (essential component of fungal cytoplamic membrane)
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