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14 Cards in this Set

  • Front
  • Back
What do you want to know about each antibiotic?
(7 things)
1)Spectrum of action
2)Mechanism of action
4)Distribution (penetration of target tissue)
5)Drug interactions
7)Toxicity and adverse effects
Define MIC
MIC (Minimum inhibitory concentration)- lowest concentration of the drug that inhibits growth after 18-24 hrs of incubation in vitro
Define MBC
MBC (Minimum bactericidal concentration)- lowest concentration of the drug at which 99.9% of a culture is killed after 18-24 hrs incubation in vitro
Define PAE
PAE (post-antibacterial effect)- When suppression of bacterial growth continues after the antibiotic concentration falls below the bacterial MIC
Define Time-dependent killing
Bactericidal effects only occur during the time when the antibiotic is maintained above the MIC
Drugs that Inhibit Cell Wall Biosynthesis/Membrane potential
Glycopeptides (vancomycin, teicoplanin)
β-lactams (penicillins, cephalosporins, monobactams, carbapenems, carbacephams)
Lipopeptides (daptomycin)
Drugs that inhibit protein synthesis
Oxazoladinones, tetracyclines, aminoglycosides, chloramphenicol, loncosamines, macrolides, Type B streptogramins, ketolides
Drugs that inhibit Nucleic Acid Biosynthesis
Sulfonamides, trimethroprim, floroquinolones, nitroimidazole, rifamycin
Bactericidal Antibiotics that are Concentration-dependent (4)
Aminoglycosides, quinolones, lipopeptide, ketolides
Bactericidal Antibiotics that are Time-dependent
β-lactams, cephalosporins, carbacepham, Vancomycin (selectively)
Bacteriostatic Antibiotics
Chloramphenicol, Clindamycin, Tetracycline, Macrolides, Sulfonamides, Oxazolidinones
Type 1 Pharmacokinetics
Conc-dep killing, significant PAE
Aminoglycosides, daptomycin, quinolones, ketolides
Type 2 Pharmacokinetics
Time-dep killing, no PAE
β-lactams, Vancomycin (selectively)
Type 3 Pharmacokinetics
Time-dep effect, moderate to prolonged PAE
Chloramphenicol, Clindamycin, Tetracycline, Macrolides, Sulfonamides, Oxazolidinones, Glycopeptides, Streptogramins