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10 Cards in this Set
- Front
- Back
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what is the mechanism of action of Sulfonamides?
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Inhibit dihydropterate synthase, the first step in FH4 synthesis. Attachment of pteridine ring to PABA (para-aminbenzoic acid)
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Cause greater risk of hemolytic anemia in G6PD deficient pts
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nitrofurantoin, sunfonamides, chloramphenicol
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Sulfonimides potentiate hypoglygemia by mimicking what, and what is the mechanism?
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Sulfylureas block K+ channels in the islets of lanerhaun. Cells depolarize and release insulin.
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Aminoglycosides cause toxicity to what?
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Ototoxic (usually permanent) nephrotoxic (usually reversible)
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What type of antibiotic is a sulfonamide and against what type of bacteria are they effective?
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Static, affective against a wide range of Gram + and - bacteria.
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What is required for the synthesis of Thymidine?
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N5-N10- methelene-tetrahydrofolate, Thymidylate synthase dUMP → TMP
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What does FH4 do?
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Transfer of methyl groups such as in the transfer from N5-N10-methylene-tetrahydrofolate to dUMP → TMP
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Trimethoprim: action and side effects?
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inhibits bacterial DHFR. Side effects: blood dyscrasias
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Pyrimethamine: action ?
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antimalarial – inhibits protozoal DHFR
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Methotrexate: action?
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Inhibits Mammalian, bacterial, and protozoal DHFR. Used to treat psoriasis and various cancers.
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