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16 Cards in this Set
- Front
- Back
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this generation of cephalosporin has gram positive and modest gram negative activity
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1st
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this generation of cephalosporin has increased stability to hydrolysis by B-lactamase
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4th
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this generation of cephalosporin has less activity against gram positive bacteria than the first gen, but has broad-spectrum activity against most gram negative bacteria
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3rd
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this generation of cephalosporin has better activity against gram negative bacteria and some of them have anti-anaerobe activity with limited activity against gram positive
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2nd
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This Class of Penicillin is active against gram positive bacteria
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natural pencillin:
Pen G |
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This Class of Penicillin:
active against gram pos, resistanc to penicillinase |
Penicillinase-Resistant
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This Class of Penicillin:
active against gram positive and some gram negative bacteria |
Aminopenicillin
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This Class of Penicillin
Ampicillin-like spectrum plus activity against some gram neg bacteria |
Carboxypenicillins
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This Class of Penicillin
more active against Pseudomonas and Klebsiella and anaerobes |
Ureidopenicillins
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glycopeptide produced by streptococcus orientalis
used to treat sepsis or endocarditis caused by MRSA staphylococcus (gram positive) |
Vancomycin
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T/F
Vancomycin binds to the D-Ala - D-Ala terminus of pentapeptide that is linked to NAM. This sterically interfes with elongation of the peptidoglycan chain. |
True
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T/F
Vancomycin can be prescribed and dispensed in your local community pharmacy for infections. |
False, it is very toxic and hard to administer..has to be admin IV
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T/F
Vancomycin is a beta-lactam antibiotic that inhibits bacteria cell-wall synthesis |
False..it is a glycopeptide
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How does a bacteria become resistant against vancomycin?
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D-Ala-D-Ala is replaced by D-Ala-D-lactate. Vancomycin's affinity to this is very low
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T/F
Non-Classical b-lactams all contain a B-lactam ring, and are NOT resistant to B-lactams |
False..they ARE resistant.
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B-lactamase inhibitors do not have high intrinsic antibacterial activity..but what do they do?
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inhibit most plasmid-mediated penicillinases found in gram negative bacteria..used to extend spectrum of pencillins which are susceptible to penicillinase
eg) clavunic acid + amoxicillin= Augmentin |
