Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
Ampicillin What's its classification |
Beta-lactam |
|
Ampicillin Mechanism of action |
the antibiotic binds to specific PBPs (transpeptidase, carboxypeptidase) in the bacterial cell wall and inhibits assembly of the peptidogycan chains. This, in turn, activates autolysins that degrade the cell wall, resulting in bacterial cell death. |
|
Vanomycin What's the classification? |
Glycopeptide |
|
Vanomycin What's the mechanism of action? |
Interactswith the alanine-alanine termini of the pentapeptide side chains, which interferes sterically with formation of the bridges between peptidoglycan chains. Cell wall synthesis is disrupted and Gr+ bacteria dies. 8
|
|
Colistin/Polymixins B&E (same thing) What's the classification |
polypeptide |
|
Colistin/Polymixins B&E What's the mechanism of action? |
Inserts into bacterial membranes like detergentsby interacting with lipopolysaccharides and the phospholipids in the outermembrane, producing increased cell permeability and eventual cell death. |
|
Isoniazid What's the classification? |
Anti-cell wall myobacteria / no classification |
|
Isoniazid What's the mechanism of action? |
The desaturation of the long-chain fatty acids and elongation of fatty acids and hydroxyllipids are disrupted. Kill actively replicating mycobacteria. (inhibits mycolic acid (fatty acid in cell walls) synthesis) |
|
Gentamicin What's the classification |
Aminoglycoside |
|
Gentamicin What's the mechanism of action? |
Passes through the cell wall and membrane and inhibits bacterial protein synthesis by irreversible binding to the 30S ribosomal subunit. Causes premature release and misreading of mRNA. |
|
Tobramycin
|
Aminoglycoside |
|
Tobramycin What's the mechanism of action? |
Passes through the cell wall and membrane and inhibits bacterial protein synthesis by irreversible binding to the 30S ribosomal subunit. Causes premature release and misreading of mRNA. |
|
Doxycycline What's the classification? |
Tetracycline |
|
Doxycycline What's the mechanism of action |
Inhibit protein synthesis in bacteria by binding reversibly to the 30S ribosomal subunit, and blocks tRNA binding to the 30S-mRNA complex. |
|
Erythromycin What's the classification |
Macrolide |
|
Erythromycin What's the mechanism of action? |
Blocks polypeptide elongation by reversibly binding to the 23S ribosomal RNA (rRNA) of the 50S ribosomal subunit, which blocks polypeptide elongation. |
|
Ciprofloxacin What's the classification? |
Quinolone |
|
Ciprofloxacin What's the mechanism of action? |
It’s a synthetic chemotherapeutic agent that inhibits bacteria DNA topoisomerase type II (gyrase) or topoisomerase type IV. Topoisomerases are required for DNA replication, recombination, and repair. |
|
Trimethoprim What's the classification |
Antimetabolite (sulfonamide) |
|
Trimethoprim What's the method of action? |
Antimetabolites compete with p-aminobenzoicacid, which prevents synthesis of folic acid. Timethoprim interferes with folicacid metabolism by inhibiting dihydrofolate reductase. Thus blocks the formation of thymidine, somepurines, methionine, and glycine. |
|
Dapsone What's the classification |
Antimetabolite (sulfonamide) |
|
Dapsone What's the mechanism of action? |
Antimetabolites compete with p-aminobenzoic acid, which prevents synthesis of folic acid. Timethoprim interferes with folic acid metabolism by inhibiting dihydrofolate reductase. Thus blocks the formation of thymidine, some purines, methionine, and glycine. |