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17 Cards in this Set
- Front
- Back
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Tetracycline
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Blocks binding of aminoacyl-tRNA to A-site of ribosome
Treat infections in the respiratory tract, sinuses, middle ear, urinary tract, intestines, and gonorrhea Prokaryotes |
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Streptomycin
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Prevents the transition from initiation complex to chain elongating ribosome and also causes miscoding
Prokaryotes |
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Chloramphenicol
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Blocks the peptidyl transferase reaction on ribosomes
Broad spectrum, gram positive and negative Prokaryotes |
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Erythromycin
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Blocks the translocation reaction on ribosomes
Good for gram positive infections(pneumonias, staphylococcus, respiratory infections Prokaryotes |
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Rifamycin
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Blocks initiation of RNA chains by binding to RNA polymerase (prevents RNA synthesis)
Prokaryotes |
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Puromycin
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Causes the premature release of nascent polypeptide chains by its addition to growing chain end
Prokaryotes and Eukaryotes |
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Actinomycin D
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Binds to DNA and blocks the movement of RNA polymerase
Prokaryotes and Eukaryotes |
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Cycloheximide
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Blocks the translocation reaction on ribosomes
Eukaryotes |
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Anisomycin
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blocks the peptidyl transferase reaction on ribosomes
Eukaryotes |
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alpha-Amanitin
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Blocks mRNA synthesis by binding preferentially to RNA polymerase II
Cause sever abdominal upset, then liver, kidney, and circulatory system failure. Death usually in 10 days Flat top mushrooms Eukaryotes |
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Macrolides
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Relatives of erythromycin, kill more with fewer side effects
Polyketide class of natural products Treatrespiratory tract infections, genital, gastrointestinal tract, soft tissueinfections caused by susceptible strains of specific bacteria. Bind ribosomes, mainly bacteriostatic but can be cidal |
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Aminoglycosides
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treat gram-negative bacteria
can't be given by mouth, must be injected which can damage ears and kidneys |
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Cephalosporins
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Grouped into generations with each newer having grater gram negative antimicrobial properties
treat pneumonia, strep, staph, tonsilitis, bronchitis, otitis media, skin infections, gonorrhea, surgical prophylaxis bacteriocidal by inhibiting cell wall synthesis related to penicillins |
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Fluroquinolones
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Broad spectrum antibiotics
Treat urinary tract infections, skin infections, and respiratory infections. Side effects mainly digestive interfere with ability to make DNA rapidly growing resistance |
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Penicillins
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First Discovered antibiotic(alexander Fleming 1929)
Treat skin infections, dental infections, ear infections, respiratory tract infections, urinary tract infections, gonorrhea Block the construction of bacteria cell walls, causing the walls to break down, killing the bacteria Combined with beta lactamase inhibitors to protect from destruction very safe other than allergic reactions |
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Tetracyclines
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Treat broad spectrum: mild acne, lyme disease, upper respiratory tract infections, rocky mountain spotted fever, urinary tract infections, STDs, typhus
popular when discovered in 1940s but not used to often because softens and yellows teeth enamel. |
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Kirromycin
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Stops recycling of EF-TU
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