• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/14

Click to flip

14 Cards in this Set

  • Front
  • Back
Penicillins
Alter bacterial cell wall formation resulting in cell lysis with continued organism growth.
(BACTERICIDAL)
Cephalosporins
Alter bacterial cell wall formation - same as penicillin.
(BACTERICIDAL)
Aminoglycosides
Bind to 30S ribosomes, resulting in irreversible inhibition of protein synthesis.
(BACTERICIDAL)
Fluoroquinolones
Inhibit bacterial DNA gyrase, an enzyme required for bacterial DNA replication, transcription, repair, and recombination.
(BACTERICIDAL)
Metronidazole
Undergoes structural change (reduction of its nitro group) once inside its target organism, resulting in liberation of unstable intermediate compounds and free radicals, which disrupt bacterial DNA.
(BACTERICIDAL)
Trimethoprim/sulfonamide
Acts synergistically to inhibit the synthesis of folic acid, a compound necessary for microbial production of DNA.
Sulfonamides block the firt step in folic acid sunthesis, and trimethoprim blocks the second step in this pathway.
(BACTERICIDAL)
Vancomycin
Disrupts biosynthesis of peptidoglycan, the major cell wall polymer, thus inhibiting cell wall synthesis (this differs from mechanism of beta lactam antimicrobials)
Inhibits bacterail RNA synthesis and alters membrane permeability
(BACTERICIDAL)
Rifampin
Forms a stable drug-enzyme compex with the bacteial RNA polymerase, the enzyme responsible for DNA transcription, thus inhibiting its function.
(BACTERICIDAL)
Tetracycline
Binds reversibly to the 30S ribosomal subunit and inhibit microbial protein synthesis
Chloramphenicol
Binds reversibly to the 50S ribosomal subunit and inhibit microbial protein synthesis.
Can inhibit mammalian mitochondria protein synthesis.
Erythromycin (Macrolide)
Binds reversibly to the 50S ribosomal subunit and inhibit microbial protein synthesis
Tylosin (Macrolide)
Binds reversibly to the 50S ribosomal subunit and inhibit microbial protein synthesis
Lincomycin
Binds reversibly to the 50S ribosomal subunit and inhibit microbial protein synthesis
Clindamycin
Binds reversibly to the 50S ribosomal subunit and inhibit microbial protein synthesis
Antagonism exists between lincosamides, macrolides, and chloramphenical because of the similiar site of action.