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47 Cards in this Set
- Front
- Back
AG coverage
|
G- bacilli
aerobic PPEAKS (proteus (i+), pseudomonas, enterobacter, acinetobacter, klebsiella, serratia) anti-TB staph (with beta-lactam) |
|
1st gen FQ coverage
|
good G-
enterobacteriaceae |
|
2nd gen FQ coverage
|
excellent G-
enterobacteriaceae atypicals pseudomonas fair G+ |
|
3rd gen FQ coverage
|
excellent G-
enterobacteriaceae atypicals pseudomonas better G+ strep pneumoniae |
|
4th gen FQ coverage
|
excellent G-
less enterobacteriaceae atypicals pseudomonas G+ ANAEROBES (B.Frag) |
|
chloramphenacol coverage
|
G+
G- ANAEROBES (B.Frag) atypicals |
|
clindamycin coverage
|
G+
ANAEROBES (B.Frag, propionbacterium-acne) |
|
erythromycin coverage
|
G+
atypicals poor ANAEROBE campylobacter jejuni |
|
clarithromycin coverage
|
G+
atypicals H.Flu Legionella M.Cat Chlamydia poor ANAEROBE campylobacter jejuni |
|
azithromycin coverage
|
less G+
atypicals H.Flu Legionella M.Cat Chlamydia |
|
telithromycin coverage
|
G+
H.Flu Legionella M.Cat Chlamydia atypicals poor ANAEROBE strep pneumoniae resistant to Pen and Ery |
|
tetracycline coverage
|
G+ (many staph/strep resistant)
G- (pseudomonas/enterobacteriaceae resistant) E.Coli (traveler's diarrhea) H.Flu M.Cat ANAEROBES Atypicals Chlamydia (DOC) syphillis mycoplasma pneumoniae legionella protozoa |
|
tigecycline coverage
|
G+
MRSA MRSE VISA Pen-res strep pneuomoniae Vanco-sensitive entero faecalis/faecium VRE G- enterobacteriaceae acinetobacter baumanni NO pseudomonas/proteus anaerobes (B.Frag, C.Diff, C.Perf) atypicals mycobacterium |
|
streptogramin coverage
|
G+
MRSA VRE VISA E. faecium NO G- NO E. faecalis |
|
linezolid coverage
|
G+
E. faecalis/faecium VRE MRSA MRSE VISA VRSA Pen-res strep listeria corynebacterium ANAEROBES C.Perf |
|
daptomycin coverage
|
G+
MRSA MRSE VISA VRE E. faecalis/faecium NO G- NO pneumonia (inactivated by pulm surfactant) |
|
metronidazole coverage
|
anaerobes (B.Frag, C.Dif)
protozoa NO aerobes |
|
AG MOA
|
1. inhibit bacterial protein synthesis
2. misread genetic code 3. cell becomes leaky |
|
streptomycin binds...
|
S12 on 30S
|
|
AG's bind...
|
multiple sites on 30S and 50S
|
|
novobiocin binds...
|
beta subunit on DNA gyrase to inhibit relaxation
|
|
FQs bind...
|
alpha subunit on DNA gyrase to inhibit resealing
|
|
chloramphenicol binds...
|
A window on 50S
inhibits peptidyltransferase |
|
clindamycin binds...
|
A window on 50S
inhibits peptidyltransferase |
|
marcolides bind...
|
P site on 50S
|
|
telithromycin binds...
|
50S
|
|
tetracyclines bind...
|
A site on 30S
|
|
tigecycline binds...
|
A window on 30S
|
|
Q/D binds...
|
50S
|
|
linezolid binds...
|
23S on 50S
inhibits 30S and 50S from associating |
|
daptomycin binds...
|
cytoplasmic membrane
depolarizes it to inhibit DNA/mRNA synthesis and cause leakage |
|
metronidazole MOA
|
nitro group reduced to free radicals which cause cellular damage
|
|
INH MOA
|
inhibits mycolic acid synthesis
|
|
rifampin MOA
|
binds to beta subunit of DNA dependent RNA polymerase
broader spectrum |
|
ethambutol MOA
|
inhibits arabinosyl transferase/polymerization of arabinogalactan
|
|
PZA MOA
|
unknown
prodrug activated in acidic environment of lysosomes and macrophages |
|
dapsone MOA
|
inhibits dihydropteroate synthetase
|
|
clofazimine MOA
|
inhibits template function
|
|
drugs that bind 30S
|
AG's - multiple sites
Streptomycin - S12 Tetracycline - A window Tigecycline - A window |
|
drugs that bind 50S
|
AG's - multiple sites
macrolides - P site chloramphenicol - A window clindamycin/lincomycin - A window linezolid - 23S Q/D telithromycin |
|
drugs that bind DNA gyrase
|
novobiocin - beta subunit
FQ's - alpha subunit |
|
CYP inhibitors
|
"Clearly Cool Ken's Vehicle Is Equally Quick"
Chloramphenicol/Clarithromycin (3A4) Cimetidine Ketoconazole Valproic acid Isoniazid Erythromycin/telithromycin (3A4) Quinolones (1A2), quinine, quinidine, Q/D (3A4) |
|
CYP inducers
|
"Barbie's Car Goes Real Phast"
Barbiturates Carbamazepine Griseofulvin Rifampin Phenytoin |
|
bacterioSTATIC drugs
|
DELT CK TM QD
Daptomycin Ethambutol Linezolid Tetracycline Chloramphenicol Ketolide Tigecycline Macrolides Q/D when given separately |
|
bacteriCIDAL drugs
|
DR FAMMM QD
Daptomycin (G+) Rifampin FQ's AG's Methenamine Metronidazole Marolides (Strep. pneumo) Q/D when given together |
|
isoniazid (INH) is static when __ and cidal when ___
|
static - intracellular (slow growing) organisms
cidal - extracellular organisms |
|
biliary elimination drugs
|
CMT TT Q/D R
Clindamycin Macrolides Telithromycin Tetracyclines (doxy/mino - lipophilic) Tigecycline Q/D Rifampin |