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25 Cards in this Set
- Front
- Back
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Examples of BACTERIOSTATIC abx?
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Sulfonomides & Tetracycline.
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Name 2 bacteriocidals-killers.
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PCN, Streptpmycin.
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One portion of the lipopolysaccharide that can induce fever, platelet aggregation, vasc permeability.
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Endotoxins
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What are the most widely used Beta lactam abx?
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PCNs, cephalosporins, beta-lactamase inhibitors.
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Name the 4 Beta-lactam abxs.
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Carbapenems
Cephalosporins Monobactam PCN |
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Spectrum of Pen G & Pen V?
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Narrow.
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Name 2 penicillinase-resistant penicillans.
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Dicloxacillin
Nafcillin |
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Is Amoxcillin an extended spectrum PCN?
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Yes.
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Pen G route of administration.
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Intramuscular-severely affected by gastric acid.
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Typical uses for Pen G.
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STREP, Syphilis (T. Pallidu), endocarditis (V. strep, enterococci), pneumonia (pnemococci) meningococci also.
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Pen V route of admin?
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Oral.
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Indications for pen V
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Pharyngitis (Strep)
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Procaine Pen G. (IM)
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Produces higher plasma concentrations for for about 24 hours.
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Benzathine Pen G. (IM)
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Provides low plasma concentrations for several weeks.
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Uses for Pen G?
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Syphilis, edocarditis, meningitis, pneumonia.
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Use for Pen V?
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Pharyngitis.
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Inications for Dicloxacillin?
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PCN-resistant strains of staphy (osteomyelitis or skin and soft tissue infections)
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Uses for Amoxicillin?
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Resp infxs, OM, sinusitis, bronchitis & CAP.
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3 ways by which bact restist PCNs & other Beta-lactam abxs.
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Inactivation of the drug by Beta-lactamase enzs (cleave amide group), reduced afinity of PBPs, alteration of membrane porin size so drug can't go in cell.
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List major adverse effects of PCNs.
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Skin rashes, papules, urticaria, anaphylactic shock, serum sickness, interstital nephritis, & hepatitis.
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Microbes killed by 1st gen Cephalosporins?
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Strep & methicillin-sensitive staph. (G + -) : enteric bacili, E. Coli, Klebsiella peumoniae.
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Infections txd by 1st gen Cephalosporins?
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Skin & ST (G +), uncomplicated UTIs.
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Microbes killed by 2nd gen Cephalosporins?
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Greater G negative bacilli, incl H. I.
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Infections Tx'd with 2nd gen Cephalosporins?
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Resp tract infxs, OM (H.I), CAP, intra abd, gynecologic, & biliary tract infxs.
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Surgical prophylaxis (G neg).
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another use for 2nd gen Cephalosporins.
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