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8 Cards in this Set

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Which Abx act on CELL WALL
Beta Lactams

Glycopeptides: VANC, TICOPLENIN
Mech of action of cell wall Abx
Peptidoglycan backbone with pentapeptide cross-links

Transpeptidase (PBPs) make cross-links = 2-ALA BOND

Beta lactams act on transpeptidase (PBPs)
Mech of R to cell wall Abx?
Altered TARGET SITE

PORIN CHANNEL alteration

ENZYMATIC DEGREDATION

EFFLUX
Cell wall Abx: BINDING SITE alterations
MRSA PBP2 alt. MecA gene

DRSP
VRE mech
HAX transposon inserted into genetic material

H=VanH catalyses lactate from pyruvate

A=VanA gene, ligase: d-ala/d-ala --> d-lac/d-ala

X=peptidase, cleaves d-ala/d-ala bond
VISA
VANC INT SA

thickened cell wall w/ heaps of d-ala/d-ala

sequesters Abx
Which bug affects porin channel alterations?
Pseudomonas
Enzymatic degredation?
Class A: TEM1, SHV (plasmids, transposon)

B: metallo enzymes (carbapenems), VIM, IMP genes

C: chromosomal cephalosporinases (ESCAPPM)