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8 Cards in this Set
- Front
- Back
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Which Abx act on CELL WALL
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Beta Lactams
Glycopeptides: VANC, TICOPLENIN |
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Mech of action of cell wall Abx
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Peptidoglycan backbone with pentapeptide cross-links
Transpeptidase (PBPs) make cross-links = 2-ALA BOND Beta lactams act on transpeptidase (PBPs) |
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Mech of R to cell wall Abx?
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Altered TARGET SITE
PORIN CHANNEL alteration ENZYMATIC DEGREDATION EFFLUX |
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Cell wall Abx: BINDING SITE alterations
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MRSA PBP2 alt. MecA gene
DRSP |
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VRE mech
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HAX transposon inserted into genetic material
H=VanH catalyses lactate from pyruvate A=VanA gene, ligase: d-ala/d-ala --> d-lac/d-ala X=peptidase, cleaves d-ala/d-ala bond |
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VISA
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VANC INT SA
thickened cell wall w/ heaps of d-ala/d-ala sequesters Abx |
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Which bug affects porin channel alterations?
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Pseudomonas
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Enzymatic degredation?
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Class A: TEM1, SHV (plasmids, transposon)
B: metallo enzymes (carbapenems), VIM, IMP genes C: chromosomal cephalosporinases (ESCAPPM) |
