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14 Cards in this Set
- Front
- Back
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B-lactams |
Prevent cell wall synthesis by binding to PBPs & prevent cross-linking of peptidoglycan strands |
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Glycopeptides |
Inhibit cell wall synthesis by binding to terminal d-ala-d-ala on peptide, preventing glycosylase enzyme from adding PG monomer onto PG chain |
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Polymyxin |
Bind to LPS on outer membrane surface disrupting & penetrating cytoplasm causing a leakage of cytoplasm contents |
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Lipopeptides |
Alters curvature of membrane, creating holes that leak ions causing rapid depolarisation & loss of membrane potential |
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Trimethoprim |
Disrupts folate synthesis by competing with dihydrofolic acid for the enzyme dihydrofolate reductase |
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Fluoroquinolones |
Bind to and inhibit type II & IV topoisomerases which are required for DNA replication & transcription |
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Rifamycins |
Forms a stable complex with RNA polymerase & suppresses the initiation of RNA synthesis |
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Macrolides |
Bind to 50S subunit and decrease translocation & release of tRNA |
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Lincosamides |
Bind to 50S subunit and cause premature dissociation of peptidyl-tRNA from the ribosome |
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Aminoglycosides |
Irreversibly bind to the A-site on the 16S rRNA in the 30S subunit causing misreading of mRNA, interference of translocation of tRNA and disrupts membrane permeability |
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Tetracyclines |
Reversible bind to the A-site on the 16S rRNA in the 30S subunit which blocks the binding of aminoacyl tRNA to mRNA |
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Nitronimidazoles |
Cause strand breakage in the bacterial DNA |
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Fusidic acid |
Affects the EF-G which supplies energy for translocation |
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Chloramphenicol |
Binds to the 50S subunit and prevents peptide bond formation |
