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33 Cards in this Set
- Front
- Back
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What drugs are good penetrators of the blood brain barrier?
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Choramphenicols (amphenicols)
Doxyxyxline/minocycline (tetracyclines) Metronidazole 3rd generation cephalosporins Floroquinolones Sulfonamides Imipenem - carbapenams Aztreonam - monobactams |
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What drugs are bacteriostatic?
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tetracyclines
amphenicols sulfonamides diaminopyrimidines Lincosamides Macrolides |
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What drugs are bacteriocidal?
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Penicillin
cephalosporin Fluoroquinolines aminoglycosides metronidazole bacitracin polymyxin vancomycin Rifampin |
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What are concentration dependant drugs?
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aminoglycosides (high)
Fluoroquinolones (high) metronidazole |
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What are time dependant drugs?
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penicillims
cephalosporins tetracyclines amphenicols macrolides lincosamides sulfonamides Diaminopyimidines monobactams (aztreonam) |
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What drugs have potential toxicity at normal doses?
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aminoglycosides (nephrotoxic)
amphenicols (aplastic anemia in humans watch out in food animals) sulfonamides (hepatotoxic) metronidizole (long term use) |
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What antibiotics are good for intracellular bacteria?
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tetracyclines
amphenicols metranidazole works on chlamydia, ehrlichia and RMSF |
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What systemic drugs are good for tough gram negative aerobes?
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Aminoglycosides
Fluoroquinolones Potentiated sulfonamides |
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What systemic drugs are good for pseudomonas?
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Ticarcillin (Pen)
Cefoperazone & ceftazadime Aminoglycosides Aztreonam (Monobactam) Imipenem (Carbapenam) |
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What systemic drugs are good for tough anaerobes?
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metronidazole
Clindamycin (Lincosamide) Cefoxiti |
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What antibiotics are used against mycoplasma?
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Fluoroquinolones
Aminoglycosides Tetracyclines Lincosamides Macrolides |
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What are good broad spectrum combination antibiotics?
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Broad spectrum penicillin w/ fluoroquinolone or aminoglycoside
First generation cepholosporin w/ fluoroqunolone or aminoglycoside Clindamycin w/fluoroquinolone or aminoglycoside |
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What are poor combination antibiotics?
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Fluoroquinolines and aminoglycoside (both 50S inhibitors)
Beta lactams (like rapid growing bacT) and any static antibiotic |
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What antifungals are both broad spectrum topical and systemic?
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Amphotericin B (Polyene), ketoconazole and itraconazole (Azoles)
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Which anitfungals are narrow spectrum topical and systemic?
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Terbinifine (and tolnaflate)
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What are the cidal antifungals?
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Amphotericin B, terbinifine, flucytosine
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What are the static antifungals?
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Azoles, Griseofulvin (and Lufenron)
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What are the systemic antifugals?
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Griseofulvin and flucanazole
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What are the antistaphylococcal drugs?
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methicillin
oxycillin cloracillin didixacillin nafacillin (bile excreter) clindamycin (lincosamide) |
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What drugs act on the 30S ribosome?
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tetracyclines
aminoglycosides |
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What drugs act on the 50S ribosome?
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Amphenicols
Lincosamides Macrolides |
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What drugs are cell wall inhibitors?
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Beta Lactams:
penicillins cephalosporins - cefalexin Monobactams - azotreman Carbapenems - impenem Non Beta Lactams: Vancomycin - MRSA Bacitration - G+ (topical) |
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What is a narrow spectrum Beta Lactams?
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Penicillin
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What is a broad spectrum Beta Lactam?
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Ampicilin
Amoxicillin |
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What is a augmented Beta Lactam?
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clavamox
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What is an antistaphylococcal Beta Lactam?
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methicilin
oxocillin cloracillin nafacillin |
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What is a antispseudomonal Beta Lactam?
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Carbenicillin
careillin |
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What drugs disrupt cell membranes?
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polymixins (topical gram -)
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What drugs inhibit metabolism?
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Sulfonamides
Diaminopyrimidines |
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What drugs inhibit replication?
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Fluoroquinolines -enrofloxacin
Metronidazole - anaerobes Rifampin - Erythromycin Rhodococcus equi |
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What antibiotics cause neuromuscular blockade?
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Lincosamides
aminglycosides |
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What drugs are used in bovine respiratory disease?
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florfenicol (amphenicols)
Timicosin ( macrolides) |
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What drugs should you not use in food animals?
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chloramphenicols
causes fatal aplastic anemia in human |
