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33 Cards in this Set

  • Front
  • Back
What drugs are good penetrators of the blood brain barrier?
Choramphenicols (amphenicols)
Doxyxyxline/minocycline (tetracyclines)
Metronidazole
3rd generation cephalosporins
Floroquinolones
Sulfonamides
Imipenem - carbapenams
Aztreonam - monobactams
What drugs are bacteriostatic?
tetracyclines
amphenicols
sulfonamides
diaminopyrimidines
Lincosamides
Macrolides
What drugs are bacteriocidal?
Penicillin
cephalosporin
Fluoroquinolines
aminoglycosides
metronidazole
bacitracin
polymyxin
vancomycin
Rifampin
What are concentration dependant drugs?
aminoglycosides (high)
Fluoroquinolones (high)
metronidazole
What are time dependant drugs?
penicillims
cephalosporins
tetracyclines
amphenicols
macrolides
lincosamides
sulfonamides
Diaminopyimidines
monobactams (aztreonam)
What drugs have potential toxicity at normal doses?
aminoglycosides (nephrotoxic)
amphenicols (aplastic anemia in humans watch out in food animals)
sulfonamides (hepatotoxic)
metronidizole (long term use)
What antibiotics are good for intracellular bacteria?
tetracyclines
amphenicols
metranidazole

works on chlamydia, ehrlichia and RMSF
What systemic drugs are good for tough gram negative aerobes?
Aminoglycosides
Fluoroquinolones
Potentiated sulfonamides
What systemic drugs are good for pseudomonas?
Ticarcillin (Pen)
Cefoperazone & ceftazadime
Aminoglycosides
Aztreonam (Monobactam)
Imipenem (Carbapenam)
What systemic drugs are good for tough anaerobes?
metronidazole
Clindamycin (Lincosamide)
Cefoxiti
What antibiotics are used against mycoplasma?
Fluoroquinolones
Aminoglycosides
Tetracyclines
Lincosamides
Macrolides
What are good broad spectrum combination antibiotics?
Broad spectrum penicillin w/ fluoroquinolone or aminoglycoside
First generation cepholosporin w/ fluoroqunolone or aminoglycoside
Clindamycin w/fluoroquinolone or aminoglycoside
What are poor combination antibiotics?
Fluoroquinolines and aminoglycoside (both 50S inhibitors)
Beta lactams (like rapid growing bacT) and any static antibiotic
What antifungals are both broad spectrum topical and systemic?
Amphotericin B (Polyene), ketoconazole and itraconazole (Azoles)
Which anitfungals are narrow spectrum topical and systemic?
Terbinifine (and tolnaflate)
What are the cidal antifungals?
Amphotericin B, terbinifine, flucytosine
What are the static antifungals?
Azoles, Griseofulvin (and Lufenron)
What are the systemic antifugals?
Griseofulvin and flucanazole
What are the antistaphylococcal drugs?
methicillin
oxycillin
cloracillin
didixacillin
nafacillin (bile excreter)
clindamycin (lincosamide)
What drugs act on the 30S ribosome?
tetracyclines
aminoglycosides
What drugs act on the 50S ribosome?
Amphenicols
Lincosamides
Macrolides
What drugs are cell wall inhibitors?
Beta Lactams:
penicillins
cephalosporins - cefalexin
Monobactams - azotreman
Carbapenems - impenem

Non Beta Lactams:
Vancomycin - MRSA
Bacitration - G+ (topical)
What is a narrow spectrum Beta Lactams?
Penicillin
What is a broad spectrum Beta Lactam?
Ampicilin
Amoxicillin
What is a augmented Beta Lactam?
clavamox
What is an antistaphylococcal Beta Lactam?
methicilin
oxocillin
cloracillin
nafacillin
What is a antispseudomonal Beta Lactam?
Carbenicillin
careillin
What drugs disrupt cell membranes?
polymixins (topical gram -)
What drugs inhibit metabolism?
Sulfonamides
Diaminopyrimidines
What drugs inhibit replication?
Fluoroquinolines -enrofloxacin
Metronidazole - anaerobes
Rifampin - Erythromycin Rhodococcus equi
What antibiotics cause neuromuscular blockade?
Lincosamides
aminglycosides
What drugs are used in bovine respiratory disease?
florfenicol (amphenicols)
Timicosin ( macrolides)
What drugs should you not use in food animals?
chloramphenicols

causes fatal aplastic anemia in human