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17 Cards in this Set
- Front
- Back
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state some sulfonamides
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cotrimoxazole (sulfamethoxazole/Trimethoprim)
sulfisoxazole (older drug) sulfadiazine (older drug) |
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cotrimoxazole (sulfonamide) is affected by...
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folic acid production
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sulfamethoxazole (sulfonamide) inhibits
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dihydropteroate synthase
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trimethoprim (sulfonamide) inhibits
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dihydrofolate reductase (inhibits tetrahydrofolic acid synthase)
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Sulfonamides AE:
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- sensitivity rxns
- hematologic effects and blood dyscrasias --can be fatal - GI upset |
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Tetracyclines MOA:
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typically bacteriostatic
binds to 30s ribosomal subunit blocking t-RNA binding and inhibiting translation |
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What other antibiotics bind to 30s ribosomes besides tetracyclines?
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aminoglycosides
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tetracyclines indications:
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- gram pos
-gram neg - spirochetes (Borrelia & treponema) - atypical bacteria |
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tetracyclines can treat syphillis but ___ are preferred
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penicillins
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state some tetracyclines
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- tetracycline
- doxycycline - minocycline |
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Tetracycline AE:
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- GI upset
-hypersensitivity rxns (exxagerated sunburn) - dermatological effects -chelation (binds cations, Ca2+) --don't take w/milk or tums |
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tetracycline is a ____
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tetracycline
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doxycycline is a ____
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tetracycline
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minocycline is a____
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tetracycline
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cotrimoxazole is a _____
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sulfonamide
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sulfisoxazole is a _____
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sulfonamide
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sulfadizine is a ____
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sulfonamide
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