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30 Cards in this Set
- Front
- Back
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Penicillin V is a __________
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natural penicillin
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Penicillin G is a ___________
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Natural penicillin
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Benzathine penicillin G is a _____
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Natural penicllin
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procaine penicillin G is a ______
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natural penicllin
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amoxicillin (+/- clavulanate) is a _____
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aminopenicllin
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ampicillin (+/- sulbactam) is a ______
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aminopenicillin
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dicloxacillin (PO) is a _____
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penicillinase resistant penicillin
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nafcillin is a _____
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penicllinase resistant penicillin
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oxacillin is a ______
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penicillinase resistant penicillin
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carbenicillin is a _______
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extended spectrum penicillin --carboxy
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ticarcillin (+/- clavulanate) is a ______
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extended spectrum penicillin ---carboxy
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piperacillin (+/- tazobactam) is a ____
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extended spectrum penicillin ---urueio
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mezlocillin is a ________
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extended spectrum penicillin --urueio
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azlocillin is a _______
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extended spectrum penicillin --urueio
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Quinolones (fluroquinolones) MOA:
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- bactericidal
-inhibits DNA enzymes (topoisomerase, gyrase) that are needed for DNA replication |
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Quinolones (fluroquinolones) indications:
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Very broad spectrum activity
- gram pos - gram neg -LIMITED anaerobic coverage - activity against enterococci - activity against P.aurginosa (ciprofloxacin) |
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State some Quinolones (fluroquinolones)
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- ciprofloxacin
- levofloxacin - ofloxacin -gemifloxacin -moxifloxacin -norfloxacin |
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commonly AE of quinolones (fluroquinolones)
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- generally well-tolerated
- GI & Hypersensitivity rxns -Arthropathy (drug affects connective tissue) *Not used in kids b/c cartilage damage |
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antituberculuosis MOA:
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-requires multiple drugs bc --difficult to eradicate pathogen (may be intracellular)
-high rate or resistance |
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indications for antituberculuosis
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tuberculosis (M. tuberculosis)
- may cover mycobacterium and other organisms as well |
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state some anti-tuberculosis drugs
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- isoniazad (mainly used)
- rifampin (mainly used) - streptomycin - prazinamide -ethambutol |
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Common AE of anti-tuberculosis drugs
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CNS and hepatic toxicity
- Rifampin may induce many drug interactions (cytocrome p450 inducer) |
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What happens if Rifampin induced cytochome p450?
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other drugs won't work --metabolized too fast ---not active
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Sulfonamides MOA:
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- typicaly bacteriostatic but can be bactericidal
- structural analogs of PABA (parabutyl amino acid) and competitively inhibit dihydropteroate synthase (produces folic acid) |
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sulfonamide indications:
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broad spectrum antibiotic
- concerns with bacterial resistance limit its use |
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isoniazid is a ______
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anti-tuburculosis drug
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rifampin is a ______
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anti-tuberculosis drug
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streptomycin is a _____
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anti-tuberculosis drug
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pyrazinamide is a ______
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anti-tuberculosis drug
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ethambutol is a ________
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anti-tuberculosis drug
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