Antibiotic Drugs Part 2

Front 1

3rd generation cephs have better coverage against gram neg bacteria specifically...

Back 1

enterobaceracea (NON-resistant), including P. aeruginosa and P. cepacia

Front 2

4th generation cephs ...

Back 2

used against Pseudomonas and enterobaceracea bacteria Resistant to 3rd generation cephalosporins (enterobaceracea cloachae)

Front 3

cefotaxime is a ______

Back 3

3rd generation cephalosporin

Front 4

cefixime is a _______

Back 4

3rd generation cephalosporin

Front 5

ceftazidime** is a ________

Back 5

3rd generation cephalosporin

Front 6

ceftriaxone is a ______

Back 6

3rd generation cephalosporin

Front 7

cefotetan is a ________

Back 7

3rd generation cephalosporin

Front 8

ceftazidime is a 3rd generation cephalosporin that has good activity against **

Back 8

pseduomonas arugenosa

Front 9

cefotetan is also a _______

Back 9

cephamycin

Front 10

cefapime is a _______

Back 10

4th generation cephalosporin

Front 11

Common adverse reactions of cephalosporins include:

Back 11

generally well-tolearted

concerns about hypersensitivity (immunological response) & anyphalactic rxns (significant bronchioconstriction)

Front 12

Name some common 3rd generation cephalosporins

Back 12

ceftazidime
cefotaxime
cefixime
ceftriaxone
cefotetan

Front 13

Name some common 4th generation cephalosporins:

Back 13

cefepime

Front 14

what is the MOA of carbapenems?

Back 14

- bactericidal
- bind to specific penicillin binding proteins

Front 15

carbapenems indications:

Back 15

- bactericidal
- broad spectrum: gram pos & neg and anerobes (esp in gut)

Front 16

Name some drugs that are carbapenems:

Back 16

- imipenem (w/cilastatin)
- meropenem

Front 17

imipenem is a _______

Back 17

carbapenem with activity against P. aurougenosa

Front 18

meropenem is a ______

Back 18

carbapenem

Front 19

common AE of carbapenems:

Back 19

generally-well tolerated

- concerns about hypersensitivity and anaphylactic rxns (usually after 2nd dose)
- maculopapular

Front 20

the MOA of Glycopeptides:

Back 20

- bactericidal
- not well-understood but binds to walls blocking glycopeptide polymerization by a different mech than beta lactams

Front 21

Indications for glycopeptides:

Back 21

- gram Positive organisms
- Aneaerobes

Front 22

Name some glycopeptide drugs:

Back 22

- vancomycin

Front 23

common AE of glycopeptides:

Back 23

- ototoxicity
- nephrotoxicity
-hypersensitivity rxns

Front 24

vancomycin is a __________

Back 24

glycopeptide

Front 25

vancomycin is given orally for 1 reason:

Back 25

- GI Problem --clostridium difficile - lives in the GI, may occcur during superinfection

pseudomembranous colitis = disease --GI swells, looks puffy, if left untreated --> explodes

Front 26

MOA of lincomycins

Back 26

- bateriostatic or batericidal depending on concentration and specific bacteria
- Binds to 50s ribosomal subunit inhibiting translation

Front 27

Indications of Lincomycins:

Back 27

> gram pos organisms
>Anaerobes

Front 28

State some lincomycin drugs:

Back 28

- clindamycin (PO, IV, vagina, topically)
- lincomycin

Front 29

common AE of lincomycins:

Back 29

pseudomembranous colitis by C. difficile

Front 30

MOA of monobactams

Back 30

- bactericidal
- binds to penicillin binding proteins (like beta lactans)

Front 31

Monobactams indications:

Back 31

- narrow spectrum of activity
- Gram neg bacteria: (*hemophilus, enterobacteriacea, P. aeruginosa)

Front 32

Name some monobactam drugs:

Back 32

aztreonam

Front 33

common AE of monobactams

Back 33

minor GI, hematological (blood cells) & hepatic effects
- hypersensitivity rxns

Front 34

clindamycin is a ________

Back 34

Lincomycin antibiotic

Front 35

lincomycin is a _______

Back 35

Lincomycin antibiotic

Front 36

Aztreonam is a ________

Back 36

monobactam antibiotic