Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
What is type of drug is aminoglycoside?
|
Antibiotic
|
|
|
what is the MOA of an aminoglycoside?
|
Bactericidal
- binds to 30s ribosomal subunit preventing translation |
|
|
What are the indications or reasons to use an aminoglycoside?
|
- Gram-negative bacteria
|
|
|
Name the aminoglycosides (antibiotic)
|
Gentamicin*
Tobramycin* Amikacin* Kanamycin Neomycin Streptomycin |
|
|
Gentamicin is a ___ and is used to treat ____
|
Gentamicin is an aminoglycoside antibiotic and it is used to treat gram neg bacteria
|
|
|
Tobramycin is a _____ and is used to treat _______
|
Tobramycin is an aminoglycoside antibiotic used to treat gram negative bacteria
|
|
|
Amikacin is a _____ and is used to treat _______
|
Amikacin is an aminoglycoside antibiotic and is used to treat gram negative bacteria
|
|
|
Kanamycin is a _____ and is used to treat _______
|
Kanamycin is an antibiotic and is used to treat gram negative bacteria
*Only used in special situations |
|
|
Neomycin is a _____ and is used to treat ______
|
Neomycin is an aminoglycoside antibiotic and is used to treat gram negative bacteria.
- topical |
|
|
Streptomycin is a ____ and is used to treat _______
|
Streptomycin is an antibiotic and is used to treat gram negative bacteria
- STDs |
|
|
common adverse rxns associated with aminoglycosides are...
|
Nephrotoxicity
Ototoxicity (Aminoglycosides = antibiotics) |
|
|
Cephalosporins are this type of drug...
|
antibiotic --they belong to a larger class of antibiotics known as Beta-lactams
|
|
|
the MOA of cephalosporin:
|
bind to specific penicillin-binding proteins (PBP) that inhibit peptidoglycan cross-linking necessary for the integrity of the cell wall
- Bactericidal |
|
|
Indications of Cephalosporin:
|
- Broad spectrum antibiotics that cover both Gram pos and Gram neg organisms
|
|
|
If cephamycins are included as cephalosporins then activity of _____ is conferred
|
...then the activity of Anaerobes is also conferred
there are cephalosporin-like compounds that have activity against anaerobic organisms |
|
|
cephalosporins are typically organized into ____ with each ___ having a different spectrum of activity
|
Cephalosporins are generally organized into generations
|
|
|
1st generation cephs have greater activity against...
|
Gram positive organisms
*does have activity against gram neg, but not as great |
|
|
2nd generation cephs have increased activity against...
|
Gram negative organisms
|
|
|
3rd generation cephs have even greater activity against ...
|
Gram negative organisms including P. aeruginosa
|
|
|
4th generation cephs have activity against....
|
Psedomonas and Enterobacteriaceae that are resistant to the 3rd generation cephs
|
|
|
Name some common 1st generation cephalosporins
|
cefazolin
cefadroxil cephalexin |
|
|
Name some common 2nd generation cephalosporins
|
cefaclor
cefuroxime cefprozil cefoxitin (cephamycin) |
|
|
Cefazolin is a ______ and is used to treat...
|
cefazolin is a 1st gen cephalosporin antibiotic and is used to treat gram positive or minor gram negative bacteria
|
|
|
cefadroxil is a _____ and is used to treat ...
|
cefadroxil is a 1st gen cephalosporin antibiotic and is used to treat gram positive or minor gram negative bacteria
|
|
|
cephalexin is a ____ and is used to treat...
|
1st gen cephalosporin antibiotic and is used to treat gram positive or minor gram negative bacteria
|
|
|
cefaclor is a _____ and is used to treat...
|
cefaclor is a 2nd gen cephalosporin antibiotic which have increased activity against gram neg organisms
|
|
|
cefuroxime is a ____ and is used to treat _____
|
cefuroxime is a 2nd gen cephalosporin antibiotic which have increased activity against gram neg organisms
|
|
|
cefprozil is a _____ and is used to treat ______
|
cefprozil is a 2nd gen cephalosporin antibiotic and has increased activity against gram neg organisms
|
|
|
cefoxitin (cephamycin) is a ___ and is used to treat _____
|
cefoxitin is a 2nd gen cephalosporin antibiotic and has increased activity against gram neg organisms
|
|
|
cefoxitin is also known as...
|
cephamycin (also has activity against anerobes)
|
