Antibacterials

Front 1

Penicillin

Back 1

Transpeptidase blocker- gram pos- rash, allergy, Coomb's positive

Hint 1

Syphillis-spirochetes and Strep

Front 2

Ampicillin

Back 2

amino penicillin, wider coverage- periplasmic space, rash and allergies, orally

Hint 2

Enterococcus

Front 3

Amoxcillin

Back 3

Transpeptidase blocker, amino modified, for gram-negative(can get into periplasmic space), rash, allergies, IV administered

Front 4

Naficillin

Back 4

Methicillin(nephrotoxic)- B-lactamase resistant, interstitial neprhotoxic (-Oxacillin)

Hint 4

Strep and Staph

Front 5

Clavulanate

Back 5

Inhibits B-lactamases, used with ampi and piper, not protective of chromosomal

Hint 5

extends toH. influenzae, Klebsiella

Front 6

Vancomycin

Back 6

Binds lipid 2, Need a lot, IV, Nephro and Ototoxic, Red Man's

Hint 6

C.dificile, MRSA, penicillin allergic

Front 7

Pipericillin

Back 7

Ureidopenicillin, Psuedomonas, better than ticaricillin

Hint 7

Psuedomonas

Front 8

Ticaricillin

Back 8

Carboxypenicillin, Psuedomonas, Platelet aggregation

Hint 8

Psuedomonas

Front 9

Cephalosporins (general)

Back 9

B-lactamase resistant, Increasing generation more gram negs, penicillin allergies

Hint 9

Reason for enterococcus prevelance

Front 10

Cefaparazone

Back 10

Bleeding, Bile, Psuedomonas

Front 11

Cefepime

Back 11

Enterobacter

Front 12

Cefazolin

Back 12

Surgical Prophaylactic

Front 13

ceftaxime

Back 13

Meningitis

Front 14

Cefamandole

Back 14

Bleeding/disulfirim

Front 15

cefotetan

Back 15

Bleeding/disulfirim

Front 16

Ceftazidime

Back 16

psuedomonas

Front 17

Ceftriaxone

Back 17

Meningitis and Bile

Front 18

Ceftaroline

Back 18

MRSA

Front 19

Ceftbiprole

Back 19

MRSA

Front 20

Imipenem

Back 20

Blactamase resistant, Seizures (cilastatin-prevents metabolism)

Hint 20

Kills all but MRSA and VRE,

Front 21

Meropenem

Back 21

Same as Imipenem- no seizures - no renal dehydropeptidase metabolism

Hint 21

Kills all but MRSA and VRE,

Front 22

Aztreonam

Back 22

Monobactam, only gram negs, good for those with B-lactam allergies

Front 23

Ertapnem

Back 23

Same as Imipenem-Narrower, Longer halflife, No Psuedomonas

Front 25

Aminoglycoside examples:

Back 25

30S, Gentamycin, Streptamycin, Tobramycin, Neomycin, Amikacin

Front 26

Aminogylcosides Counterindications

Back 26

Pregnancy, Anerobes (O2 dependent transport), LoopDiuertics(ototoxcitiy), Nm blockers(be careful)

Front 27

Gentamycin

Back 27

30s mistranslation, Synergy with Blactams- Irreverisble ototoxic, nephrotoxic, Nm blockers

Front 28

Amikacin

Back 28

Aminoglycoside- better than gentamycin - Psuedomonas-

Front 29

Tobramycin

Back 29

Aminoglycoside- better than gentamycin - Psuedomonas-

Front 30

Streptomycin

Back 30

Aminoglycoside- Y. pestis and Mycobacteria (ototoxic)

Front 32

Tetracyclines

Back 32

30S- Blocks Amino acyl Trna - less potent than doxycycline

Front 33

Tetracyclin group counterindications

Back 33

Pregnancy- Fatty liver, Teeth and calcium absorption probs, When using penicillins- antagonistic

Front 34

Doxycycline

Back 34

30S, - can be pumped out, Rikettsia and Chylmadia - not for preg, fatty liver, teeth and Ca problems, don’t use with penicillin

Front 35

Demeclocycline

Back 35

Tetracyline, SE: causes diabetes inspidus ADH antag (For SIADH-)

Front 36

Tigecylcine

Back 36

Tetracyline- Resistant to RPPS and efflux pump - No Psuedomonas

Front 38

Cholramphenicol

Back 38

50S, blocks peptidyl transferase, Aplastic Anemia, Gray baby, Bone marrow suppresion

Hint 38

Menigococcal, H. infleunze an Pneumococcola Meningitis (BBB)

Front 39

Name Macrolides

Back 39

50 S Azithromycin, Erythomycin, Clarithromycin

Front 40

Erithromycin

Back 40

Reversible 50S, Translocation inhibition, Bile, CYP inhibitor Increased Gi- motilin receptor agonist, Cholestatic hepatitis,

Front 41

Clarithromycin

Back 41

Same as Erthro -less GI

Front 42

Azithromycin

Back 42

Same as Erthro -less GI

Front 43

Clindamycin

Back 43

Lincosamide, Irreversibly binds 50S, great for anerobes, Causes c. dificile

Front 44

Sulfamethaxodole

Back 44

Stops folate no DNA - Hemolytic Anemia with G6PD , hypersensitivity, Kerticterus

Front 45

Trimethoprim

Back 45

Stops Folate, selective for bacterial, Megablastic Anemia

Front 46

Cipro

Back 46

Blocks Dna gyrase topoisomerase, no anerobes, Can inhibit Gaba- nitemares, cartilage issues

Hint 46

Potentiates Phenytion and Warfarin

Front 47

SAFE Mothers Take Care

Back 47

Sulfonamides, Aminoglyc, Fluoroquin, Erythomy, Metronidaz, Tetracyclines, Chloramphenicol

Hint 47

Nocardia, weird ones

Front 48

Buy AT 30, CELL at 50

Back 48

Aminoglyc,Tetraycy- ---Cloramphen, Erythryomy, Lincosamides, Linezolid

Front 49

Linezolid

Back 49

Kils MRSA, 50 S, Kills VRE

Front 50

Metronidazole

Back 50

Activated by reduction of drug via ferrodoxins in Anaerobes, creates cytotoxin intermediates, DISULFARIM Like reaction

Front 52

Isoniazid

Back 52

Screws mycolic acid making, baceriocidal, Hepatitis and peripheral neuropathy, inhibits Cyp

Front 53

Ethambutol

Back 53

bacteriostatic, Prevents arabinogalactan synth, Optic Nueritis

Front 54

Pyrazinamide

Back 54

Bacteriocidal, mycolic acid synt, tuberculosis SE: Hyperuricemia

Front 55

Dapsone

Back 55

Paba analog, - Hansen's disease, SE: Hemolysis, Erythema nodosum, don’t give to G6PD deficient

Front 56

Rifampin

Back 56

Transcriptional inhibitor, Tuberculosis, hansen's disease, eradication of H. influenze, Secretions=orange- induces CYP450