Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
Sulfisoxalzole
Sulfamethoxazole Sulfacetamide Mafenide |
Sulfonamides
|
|
|
Sulfonamides
MoA |
Alternate substrate that decreases thymidine and DNA synthesis
|
|
|
Crystalluria
Nausea, Vomiting Hemolytic anemia |
Side Effects of Sulfonamides
|
|
|
Trimethoprim
|
Binds and inhibits dihydrofolate reductase, reduces thymidine synthesis
Additive effect to sulfonamides |
|
|
Penicillin
MoA |
Inhibit cell wall synthesis/maintenance
Bind to specific proteins Prevents peptidoglycan crosslinking Osmotic disruption Bactericidal |
|
|
Side Effects of Penicillin
|
Hypersensitivity reactions
Anaphylactic Shock GI upset |
|
|
Methicillin
Oxacillin Ampicillin Amoxicillin Ticaricillin |
Derivatives of Penicillin
|
|
|
Clavulunate
Sulbactam |
Penicillin Additives
|
|
|
AUGMENTIN
|
Amoxicillin+Clavulunate
|
|
|
UNASYN
|
Ampicillin+Sulbactam
|
|
|
Cefazolin
Cefepime Cefetaxamine Cefotaxime Cefoxitin Cephalexin |
Cephalosporins
|
|
|
Cephalosporins
MoA and Side Effects |
Same MoA as penicillins
Side Effects=Bone marrow depression, allergic reactions and anaphylactic shock |
|
|
Vancomycin
|
Prevents peptidoglycan synthesis and causes osmotic disruption
Bacteriostatic Used for serious infections and for individuals who are allergics to other antibiotics Side Effects=anaphylactic shock, ototoxicity, nephrotoxicity |
|
|
Erythromycin
|
Inhibits 50S ribosome subunit function
Blocks bacterial protein synthesis Bacteriostatic Uses similar to penicillin-used when bacterium in resistant or patient is sensitive to penicillin |
|
|
GI disturbances
Liver Injury Cholestatic hepatitis |
Side Effects of Erythromycin
|
|
|
Clindamycin
|
Same MoA as Erythomycin
Bacteriostatic Side Effects are Colitis and diarrhea |
|
|
Tetracycline
Doxycycline Demechlorcycline Minocycline |
Tetracyclines
|
|
|
Tetracyclines
|
Inhibits 30S ribosome subunit function and blocks bacterial protein synthesis
Bacteriostatic Resistance is a problem Kills normal flora of GI tract, upsets the GI, liver damage, superinfection, renal damage vestibular damage |
|
|
Streptomycin
Neomycin Kanamycin Gentamicin Tobramycin |
Aminoglycosides
|
|
|
Aminoglycosides
|
Inhibits 30S ribosome subunit function and blocks bacterial protein synthesis
Bactericidal Not well absorbed Used for serious infections Side Effects=deafness and vestibular problems, renal toxicity, skeletal muscle weakness |
|
|
Linozelid
|
Blocks 30S ribosome subunit function and blocks bacterial protein synthesis
Bactericidal Reserved for use against Gram+ve bacteria with resistance to penicillins and cephalosporins |
|
|
Nalidixic Acid
Cinoxacin Norloxacin Ciprofloxacin |
Quinolones
|
|
|
Quinolones
|
Inhibit bacterial DNA synthesis by targeting bacterial DNA topoisomerase
Bacteriostatic/Bactericidal Used when cheaper drugs are ineffective Side Effects=cartilage erosion, nephrotoxicity, crystalluria, GI tract upset, nasea Not used on pregnant women or children |
