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11 Cards in this Set
- Front
- Back
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B-lactam drugs |
Bacteriocidal against a variety of bacteria; inhibit penicillin binding proteins. Resistance is due to synthesis of B - lactamase, decreased affinity of penicillin binding proteins, or decreased uptake. |
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Penicillins |
A family of antibacterial medications different groups vary in their spectrum of activity and their susceptibility to B - lactamases |
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Natural penicillins penicillin G penicillin V |
Active against gram-positive and a few gram-negative bacteria penicillin G is destroyed by stomach acid and so it usually must be administered by injection. Penicillin V can be taken orally |
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Penicillinase resistant methicillin, dicloxacillin |
Similar to natural penicillins, but resistant to inactivation by the penicillinase of Staphylococcus |
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Broad spectrum ampicillin amoxicillin |
similar to natural penicillins, but more active against gram-negative organisms |
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Extended spectrum ticacillin, piperacillin |
Increased activity against gram-negative rods, including Pseudomonas species |
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Cephalosporins |
a family of antibacterial medications. The later generations are generally more effective against gram-negative bacteria and less susceptible to destruction by B - lactamase susceptible to extended-spectrum B - lactamase |
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Carbapenems |
Resistant to inactivation buy P - lactamase, but susceptible to carbapenemases |
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Monobactams |
Resistant to be - lactamases but susceptible to extended-spectrum B lactamases can be given to patients who are allergic to penicillin. Primarily active against members of the family Enterobacteriaceae |
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Vancomycin |
Bacteriocidal against gram-positive bacteria binds to the peptide side chain of n - a acid Causes cell to lyse due to weakening of cell wall. Used to treat serious systemic infections and severe Clostridium difficile associated disease. And enterococci, resistance is due to a plasmid-encoded altered target. |
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Bacitracin |
Bacteriocidal against gram-positive bacteria interferes with the transport of peptidoglycan precursors. Common ingredient and non-prescription antibiotic ointments. Toxicity limits use. |
