Antiasthmatics

Front 1

Combivent

Back 1

Ipratropium Bromide and Albuterol Sulfate

Front 2

What is albuterol Sulfate MOA?

Back 2

Albuterol stimulates Adenyl cyclase, which increases c-AMPfrom ATP. Increase in c-AMP is associated with relaxation of smooth muscle causing a relaxation of the smooth muscle via stimulation of Beta 2 receptors.

Front 3

What is ipratropium Bromide MOA?

Back 3

It has anti-secretory properties from the serous and seromucous glands lining the nasal mucosa.

Front 4

What drug interactions does Combivent have?

Back 4

Sympathomimetics, tricyclic antidepressants, MAOI, and hypokalemia may worsen with nonpotassium sparing diuretics

Hint 4

4 things

Front 5

Precautions with combivent?

Back 5

1. Allergy to soy or peanuts.
2. Not for acute attacks.
3. Use with caution with people with narrow angle glacoma, prostatic hypertrophy, hypertension, or diabetes.

Front 6

What is the pregnancy category for combivent?

Back 6

C

Hint 6

Not a,b or x

Front 7

What is the major adverse effect of Combivent?

Back 7

Headache and Bronchitis

Front 8

What is Combivent normally used for?

Back 8

COPD

Front 9

What is the normal dose of COmbivent?

Back 9

2 inhilation 4x a day, max of 12

Front 10

Flovent

Back 10

Fluticasone Propionate

Front 11

What is the MOA of Flovent

Back 11

Adrenocorticoids bind to for a steroid complex. It inhibints mRNA and carrys out an antiinflammatory or antihistamine action.

Front 12

Drug interactions with Flovent.

Back 12

Do not give other steroids increase the affects and precautions

Front 13

Precautions for Flovent?

Back 13

1. Watch when patients are being transfered for systemic to aerosolized steroids. (adrenal insufficienty)
2. Not for rapid relief of brochodilation.
3. Yeast infections can occur in the oral cavity.

Front 14

What is one of the main things you need to inform the patient to do?

Back 14

Rinse their mouth out after use.

Front 15

Advair

Back 15

Flucticasone Propionate and Salmeterol Xinafoate

Front 16

What is the normal dose of Advair?

Back 16

2 puffs 12 hours apart

Front 17

What is the age cut off for a patient with Advair?

Back 17

>12 years

Front 18

What is the MOA of Advair?

Back 18

Fluticasone Propionate binds to certain receptor on the cytoplasm to form a steroid complex. It then inhibits or activates mRNA . This leads to it anti-inflammatory or antihistamine affects.
Salmeterol stimulates adenyl cyclase which increases the formation of cAMP. cAMP increases the relaxation of bronchial smooth muscle through beta 2 receptors.

Front 19

Major drug interactions of Advair?

Back 19

1. Beta blockers
2. other steroids
3. Tricyclic antidepressants
4. MAOI

Front 20

What are the precautions for Advair?

Back 20

1. Watch for adrenal insufficiency if one is transfering from aerosolized steroids.
2. Not for rapid relief.
3. watch for fungal infections.
4. Watch patients with hypertension, hyperthyroid, diabetes mellitus, and nursing mothers or pregency.

Front 21

What is the pregency category for Advair?

Back 21

C

Front 22

What are some adverse effects?

Back 22

1. Angioedema
2. Rash
3. Bronchitis
4. cough
5. Headache

Front 23

Xopenex

Back 23

Inhalation Solution
Levabuterol Hydrochloride

Front 24

Normal dose of Xopenex?

Back 24

Normal Adult dose is 0.63 TID. If they do not respond to this dose increase to 1.25 TID. Children < 12 can receive 0.31mg tid if they do not resond increase to 0.63 tid. Do not exceed this dose.

Front 25

What class is Xopenex?

Back 25

Antiasthmatic/Bronochodiator

Front 26

What is Xopenex MOA?

Back 26

Levabuterol is a sympathomimetic which stimulates adenyl cyclase which increases c-AMP. This excess for cause relaxation of smooth muscle by beta 2 adrenergic receptors. But levaabuterol has a two fold binding affinity to beta-adrenergic receptors than a racemic albuterol.

Front 27

Drug interactions with levabuterol?

Back 27

1. MAOI
2. Sympathomimetics
3. Antidepressants
4. May increase Digoxin levels

Front 28

Contraindications for Xopenex?

Back 28

1. CV disorders
2. hypertension
3. hyperthyroid
4. diabetes mellitus
5. pregnancy

Front 29

Advers effects for Xopenex?

Back 29

1. Nervousness
2. Tremors
3. anxiety
4. tachycardia
5. Dizziness

Front 30

Patient information on Xopenex?

Back 30

1. once open use within two weeks
2. Replace unused vials back in foil for storage
3. Discard if colorchange
4. protect from light

Front 31

Pregnency Class of Xopenex?

Back 31

c

Front 32

Proventil

Back 32

Albuterol Sulafate (salbutamol)

Front 33

What class is Proventil?

Back 33

Antiasthmatic/Bronchodilator

Front 34

Dose for Albuterol sulfate?

Back 34

2.5 mg QID (diluted))
0.083% solution does not need diluted

Front 35

What are two ways of taking Proventil?

Back 35

1. Maintenance - 2 inhalatons qid
2. Excercise induced - 2 inhalation 15 minutes before excerise

Front 36

What is the MOA of Abuterol Sulfate?

Back 36

increases the formation of c-AMP. This leads to relaxation smooth muscle via the beta 2 adrenergic receptors.

Front 37

Drug interactions of Albuterol Sulfate?

Back 37

1. Sympathomimetics
2. Tricyclics Antidepressants
3. MAOI
4. May increase Digoxin levels

Front 38

Precautions for Proventil?

Back 38

Use caution in patients with hypertension, CV disorders, hypertyroidism, diabetes, or pregnency

Front 39

What is the pregency category of Proventil?

Back 39

C

Front 40

What are some of the adverse effects of Proventil?

Back 40

Neausea, vomiting, nervousness, HA, Insomina Tachycardia

Front 41

Maxair

Back 41

Pirbuterol Acetate

Front 42

What class is Maxair?

Back 42

Antiasthmatic/ Bronchdilator

Front 43

How do you use Maxair?

Back 43

1 to 2 inhalations every 4 to 6 hours: max is 12

Front 44

What is Pirbuterol acetate MOA?

Back 44

Stimulates adenyl cyclases the formation of c-AMP, this causes the relaxation of smmoth muscle through the stimualtion of beta 2 adrenergic receptors

Front 45

How long does it take for effcts to work?

Back 45

30-60 minutes

Front 46

What drug interactions does Pirbuterol acetate have?

Back 46

1. Sympathomimetics
2. tricyclic antidepressants
3. MAOI

Front 47

Precautions with Maxair?

Back 47

1. hypertension
2. CV disorders
3. diabetes
4. pregnency

Front 48

What is the pregnency category?

Back 48

C

Front 49

Serevent

Back 49

Salmetrol Xinafoate

Front 50

What is the dosage of Serevent?

Back 50

1. 1 inhalation twice daily approximately 12 hours apart
2. 30 to 60 minutes prior to excercise

Front 51

What is MOA of Salmeterol Xinafoate?

Back 51

It is a sympathomimetic which stimulates adenyl cyclaeand make c-AMP , this causes a relaxation of smooth muscle through stimulation of the beta 2 adrenergic receptors

Front 52

Drug intractions with Serevent?

Back 52

1. Sympathomimetics
2. Tricyclic antidepressants
3. MAOI
4. Beta blocker can decrease the effectiveness

Front 53

Precautions of serevent?

Back 53

1. watch for increase use of short acting beta blockers, means worseing asthma
2. do not use in place of longer acting steroids
3. use with caution in diabetes, pregnency, hypertension or hyperthyroid

Front 54

what is the pregency catageory of serevent?

Back 54

C

Front 55

Adversa effct of serevent?

Back 55

1. Upper respiratory tract infections
2. simus headache
3. Lower respiratory tract infection
4. tremors
5. GI upset