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28 Cards in this Set
- Front
- Back
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What is the M.O.A. of the 4 classes?
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I = Na channel blocker
I I = Beta-blocker III = K channel blocker IV = Ca channel blocker |
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What drugs belong to class IV?
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Dilitazem, Verapamil
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What drugs belong to Ia?
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Procainamide, Disopyramide, Quinidine
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What drugs belong to Ib?
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Lidocaine, Tocainide, Phenytoin, Mexelitine
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What drugs belong to III?
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Amiodarone, Ibutilide, Dofetilide, Sotaolol
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What drugs belong to class II?
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Metoprolol, propranolol, esmolol, atenolol, timolol
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What drugs belong to Ic?
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Flecainide, propafenone
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What side effects are common to all Ia drugs?
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Torsades de pointes and thrombocytopenia
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What is a unique side effect of quinidine?
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Cinchonism - headache, tinnitus
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Which antiarrhythmics cause SLE like symptoms?
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Procainamide (Ia) and phenytoin (Ib)
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What is the indication for Ia drugs?
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WPW syndrome and reentrant tachycardia
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What is the indication for Ib drugs?
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Digoxin induced arrhythmia and post-MI ventricular tachycardias
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What is are the indications and contraindications for Ic drugs?
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Only use for refractory ventricular tachycardias that progress to v. fib. Do not use post-MI or in pts. with structural abnormalities
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Which subclass of class I increases the AP druation, EFP and QT int?
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Ia
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Which subclass of class I does not effect the AP duration?
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1c
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Which subclass of class I decreases the AP duration?
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Ib
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What EKG changes do class II drugs produce?
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PR prolongation
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What are the indications for class II drugs?
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Atrial flutter/fibrillation (slow ventricular rate not cardiovert), v tach, SVT
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What are some side effects of class II drugs?
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Impotence, asthma, sedation, bradycardia, and dyslipidemia (metoprolol only)
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What kind of changes in the action potential are seen with class III drugs?
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Increased action potential duration, increased refractory period, and increased QT (just like Ia)
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What are some side effects of Class III drugs?
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Torsades de points (except for amiodarone)
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What are the side effects of amiodarone and what labs should you monitor?
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Pulmonary fibrosis, hepatotoxicity, hypo/hyperthyroidism, corneal deposits, blue/gray skin, neuro effects, photosensitivity, constipation (check PFT, LFT, TFT)
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What is the indication for Class IV drugs?
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nodal arrythmias
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What are some side effects of class IV drugs?
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constipation, flushing, edema, heart block
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What is the use of Mg+2?
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Treatment for torsades de pointes and digoxin toxicity
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What do you treat class II overdose with?
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Glucagon
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What is the clinical use of adenosine?
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Pushes K out of cells (hyperpolarize). Used as a short acting way to stop SVT. Causes flushing, hypotension, chest pain
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What is the treatment for giving too much adenosine?
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Theophylline
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