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42 Cards in this Set
- Front
- Back
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What is teh MOA for Adevofir dipivol?
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It is phosphorylated to adefovir diphosphate and competes with endogenous deoxy adenosine triphosphate.
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What is the MOA for Entecavir?
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Phosphorylated to active TP form and inhibits HBV DNA polymerase and causes chain termination.
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What are the drugs of choice for oral facial herpes?
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Penciclovir and famiciclovir
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What are the drugs of choice for genital herpes?
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Valacyclovir, acyclovir, famciclovir
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What are the drugs of choice for herpes keratitis?
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Trifluridine, idoxuridine and viderabine
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What are the drugs of choice for neonatal herpes?
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1. Aciclovir
2. Viderabine |
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What is the drug of choice for HSV encephalitis?
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Aciclovir
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What is the drug of choice for chicken pox in immunocompromised patients?
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Aciclovir
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What are the drugs of choice for shingles?
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Aciclovir, valaciclovir or famciclovir
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What are the drugs of choice for CMV?
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1. Prophylaxis: gangcyclovir
2. Treatment: Gangciclovir, valganciclovir, foscarnet, cidofovir or fomivirsen |
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What is the best treatment of influenza?
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Prevention through immunuization
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What are the drugs of choice for Type A Influenza?
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Amantadine and rimantadine
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What are the drugs of choice for Type B Influenza?
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Zanamivir and oseltamivir
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What are the drugs of choice for HBV?
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Lamivudine, adevofir, entecavir and emitricetabine
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What are the drugs of choice for HCV?
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Pegylated IFN and ribavirin
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What would be the first line combo with a nNRTI based regimen?
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1. Efavirenz
2. Lamivudine or Emtricitabine 3. Zidovudine or Tenofovir |
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What would be the first line combo with a PI based regimen?
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1. Lopinavir/r
2. Lamivudine or Emtricitabine 3. Zidovudine or Tenofovir |
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What are the exceptions to the monotherapy rule when it comes to drug regimens?
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The use of Zidovudine or Nevirapine during pregnancy.
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What specific combos do not work even though we don't know why?
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1. Abacavir/lamivudine/tenofovir
2. Didanosine/lamivudine/tenovir 3. Didanosine/stavudine |
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What form of saquinavir should be avoided?
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Hard gel capsule form.
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What is Enfuviritide?
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Fusion prevention drug
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Zidovudine
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NRTI
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Didanosine
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NRTI
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Lamivudine
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NRTI - hep B as well
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Stavudine
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NTRI - don't use with Stavudine
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Abacavir
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NRTI - hypersensitivity rxn
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Tenofovir
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NRTI - renal dysfunction
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Saquinavir
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PI - least potent
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Ritonavir
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PI - inhibits P450
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Indinavir
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PI - crystals in urine
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Nelfinavir
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PI
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Amprenivir
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PI - little cross resistance
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Lopinavir/Ritonavir
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PI
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Atazanavir + indinavir =
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Hyperbillirubinemia
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Nevirapine
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nNRTI - used during pregnancy
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Efavirenz
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nNRTI - very potent and causes hallucinagenic dreams; teratogen
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Trifluridine
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Thymidine analog - increases dreakage of DNA - optic
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Idoxuridine
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Thymidine analog - increases dreakage of DNA - optic - less efficacious
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Vidarabine
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Adenosine analog - phosphrylated by cell enzymes; inhibits both cell and viral replication
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Ribavirin
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Guanosine analog - monophosphate form inhibits IMP dehydrogenase (purine synthesis)
Triphosphate form inhibits viral RNA pol Treatment of chronic HCV |
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Foscarnet
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Inorganic phosphate analog that inhibits DNA pol without requiring activation via phosphorylation.
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Cidofovir
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Cytosine analog phosphorylated independent of viral enzymes.
It is a diphosphate and it is given with probenecid. |
