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42 Cards in this Set

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  • Back
What is teh MOA for Adevofir dipivol?
It is phosphorylated to adefovir diphosphate and competes with endogenous deoxy adenosine triphosphate.
What is the MOA for Entecavir?
Phosphorylated to active TP form and inhibits HBV DNA polymerase and causes chain termination.
What are the drugs of choice for oral facial herpes?
Penciclovir and famiciclovir
What are the drugs of choice for genital herpes?
Valacyclovir, acyclovir, famciclovir
What are the drugs of choice for herpes keratitis?
Trifluridine, idoxuridine and viderabine
What are the drugs of choice for neonatal herpes?
1. Aciclovir
2. Viderabine
What is the drug of choice for HSV encephalitis?
Aciclovir
What is the drug of choice for chicken pox in immunocompromised patients?
Aciclovir
What are the drugs of choice for shingles?
Aciclovir, valaciclovir or famciclovir
What are the drugs of choice for CMV?
1. Prophylaxis: gangcyclovir
2. Treatment: Gangciclovir, valganciclovir, foscarnet, cidofovir or fomivirsen
What is the best treatment of influenza?
Prevention through immunuization
What are the drugs of choice for Type A Influenza?
Amantadine and rimantadine
What are the drugs of choice for Type B Influenza?
Zanamivir and oseltamivir
What are the drugs of choice for HBV?
Lamivudine, adevofir, entecavir and emitricetabine
What are the drugs of choice for HCV?
Pegylated IFN and ribavirin
What would be the first line combo with a nNRTI based regimen?
1. Efavirenz
2. Lamivudine or Emtricitabine
3. Zidovudine or Tenofovir
What would be the first line combo with a PI based regimen?
1. Lopinavir/r
2. Lamivudine or Emtricitabine
3. Zidovudine or Tenofovir
What are the exceptions to the monotherapy rule when it comes to drug regimens?
The use of Zidovudine or Nevirapine during pregnancy.
What specific combos do not work even though we don't know why?
1. Abacavir/lamivudine/tenofovir
2. Didanosine/lamivudine/tenovir
3. Didanosine/stavudine
What form of saquinavir should be avoided?
Hard gel capsule form.
What is Enfuviritide?
Fusion prevention drug
Zidovudine
NRTI
Didanosine
NRTI
Lamivudine
NRTI - hep B as well
Stavudine
NTRI - don't use with Stavudine
Abacavir
NRTI - hypersensitivity rxn
Tenofovir
NRTI - renal dysfunction
Saquinavir
PI - least potent
Ritonavir
PI - inhibits P450
Indinavir
PI - crystals in urine
Nelfinavir
PI
Amprenivir
PI - little cross resistance
Lopinavir/Ritonavir
PI
Atazanavir + indinavir =
Hyperbillirubinemia
Nevirapine
nNRTI - used during pregnancy
Efavirenz
nNRTI - very potent and causes hallucinagenic dreams; teratogen
Trifluridine
Thymidine analog - increases dreakage of DNA - optic
Idoxuridine
Thymidine analog - increases dreakage of DNA - optic - less efficacious
Vidarabine
Adenosine analog - phosphrylated by cell enzymes; inhibits both cell and viral replication
Ribavirin
Guanosine analog - monophosphate form inhibits IMP dehydrogenase (purine synthesis)

Triphosphate form inhibits viral RNA pol

Treatment of chronic HCV
Foscarnet
Inorganic phosphate analog that inhibits DNA pol without requiring activation via phosphorylation.
Cidofovir
Cytosine analog phosphorylated independent of viral enzymes.

It is a diphosphate and it is given with probenecid.