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7 Cards in this Set
- Front
- Back
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MOA of amantadine... use...
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blocks viral penetration/uncoating (M2 protein); buffer pH of endosome. Release of dopamine from nerve terminals. used for prophylaxis and tx of influenza A and Parkinsons
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toxicity and mechanism of resistance of amantadine..
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toxicity: ataxia, dizziness, slurred speech. MOR: mutated M2, most influ A resistant
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MOA and clinical use of zanamivir/oseltamivir...
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inhibits flu neuraminidase, decr release. tx both influenza A and B
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MOA of ribavirin... use... toxicity...
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competitively inhibits IMG dehydrog, thus decr syn of guanine nucleotides. Use: RSV, Hep C. Toxicity: hem anemia, teratogen
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MOA of acyclovir...
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monophophorylated by HSV/VZV Tk. guanosine analog. TriP formed by cellular enzymes. inhibits viral DNA poly by chain termination.
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clincial use of acyclovir... toxicity... MOR>..
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use: HSV, VZV, EBV (famciclovir for VZV). No effect on latent HSV or VZV. Toxicity: crystaluria, stones.
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Protease inhibitors... MOA... toxicity...
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all the navirs. MOA: block protease in progeny virions, inhibit maturation. Tox: GI intolerance, hyperglycemia, lipodystrophy, thrombocytopenia, nephropathy
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