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29 Cards in this Set
- Front
- Back
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Enfuvirtide (T-20)
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IV, disrupts gp41 conformational change assoc w/ mem fusion - fusion inhibitor
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AMD-3100
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oral or IV, CXCR4 antgonist by binding it and blocking viral gp41 binding
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Pleconaril
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oral, inhalation, inhibits uncoating by binding pocket factor resulting in blockage of NA tfer through capsid pore
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Amantadine and Rimantidine
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oral, blocks M2 ptn that creates acidic pH in endosome thereby inhibiting conformational change that would result in uncoating
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Tromantadine
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oral and topical, prevents uncoating
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IBT
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oral, causes mRNA degredation
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Type I INF
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IV, activates antiviral state, inc MHC I, inc NK cell activity
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Ribavirin
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inhalation, broad spec, A or G analogue, inhibits RDRT, inhibits 5'-CAP to mRNA
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Guanosine analogs
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chain terminators preventing replication- acyclovir, valacyclovir, penciclovir, famciclovir, ganciclovir, valganciclovir
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Cidofovir and Lamivudine
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citidine analong, prevents genome replication by chain termination
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Azidothymidine
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thymidine analog, prevents genome replication by chain termination by by inhibiting RT
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Idoxuridine and trifluorothymidine
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thymidine analogs that target rapidly diving cells - chain terminator inhibiting genome replication
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Adefovir
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adenosine anolog - chain termination
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3 HIV analogs preventing genome replication
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ddl, ddC, d4T
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Foscarnet, Efavirenz
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bind DNA pol or RT preventing nucleotide binding
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Zanamivir (Relenza) and Oseltamivir (Tamiflu)
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prevents neuraminidase cleavage of sialic acid (host receptor for virus) - virus cannot be released; taken w.i 36-48 hrs of symptoms
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Ritonavir and Liponavir
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binds protease acvitve site preventing virus maturation
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What are the preferred HAART drugs?
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Efavirenz (nonnucleotide RT inhibitor), Lopinavir-Ritonavir (protease inhibitor), Zidovudine-Lamivudine (nucleotide RT inhibitor)
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Influenza A
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Amantadine, Rimantadine, Zanamivir (Relenza), Oseltamivir (Tamiflu)
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Picornavirus
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Pleconaril
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Smallpox
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IBT
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Chronic hepatitis, HPV
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interferons
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RSV pneumonia
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Ribavirin
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Topical tx of HSV keratitis
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Idoxuridine, Trifluridine
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Genital HSV, HSV encephalitis, VZV
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Acyclovir
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oral tx for VZV - shingles
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Famciclovir, Valacyclovi
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Recurrent HSV cold sores
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Penciclovir
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HBV
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Adefovir
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CMV retinitis
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Ganciclovir, Foscarnet, Cidofovir
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