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41 Cards in this Set
- Front
- Back
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First drug for seizure |
phenobarbital |
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Partial seizure |
Simple or complex 1 hemisphere |
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Simple Seizure |
1 Muscle or 1 Body part consious 60-90secs יציאה מהכרה |
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complex seizure |
No conscious lose conscious איבוד הכרה 2minutes slow recovery (hours) |
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Tonic Clonic ( grand mal) |
rigidity, muscle shake hold your tongue to not swallow it. epilepsic |
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Abscence ( Petit mal ) |
בהייה ועפעוף מהיר 10 שניות מתחיל בשלב התבגרות 10 פעמים ביום
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Myoclonic seizure |
כיווץ שרירים מתרחש לבד במחלות ניורולוגיות אחרות
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Atonic seizure |
epilepsic lose postural tone cant hold my body |
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infantile spasm |
6months-6years tonic clonic from high fever not dangerous |
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status epilepticus |
attack after attack needs iv immediately |
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First step |
focal epileptogenesis membrane potential longer or short refractory period shorter(generalized) spikelets |
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second step |
synchronization: GPCR more exited all the brain!!!!! |
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propogation |
hetpashtot to healthy neurons |
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reasons for that?
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no magnesium which block NMDA gaba antagonist -> no inhibtion |
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Ethosuximide |
Calcium T channel blocker for the treat of abscence epilepsy (petit mal) |
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SV2A |
protein on the vesicule(glutamate) |
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CRMP-2 |
TrkB binds to tyrosine kinase |
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AMPA |
Sodium channel post synapse
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phenobarbital |
Blocks AMPA |
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NMDA |
calcium ionotropic |
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EAAT |
throws glutamate out (glia) |
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Barbiturates |
status epilepticous ? pregnant women? Meh some people get addicted to it and some kids react badly. but It's not tertogenic. |
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Deoxybarbiturate |
Primidone For simple and tonic clonic but NOT for abscence. |
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Benzodiezepen (BZ) |
Excite GABA synpase -> more inhibition (3 drugs) Diazepam(status epilepticus IV ) + petite mal Clonazepam (petite mal + myoclonic) Clorazepate (complex partial + extra ) |
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Diazepam |
Status epilpticus + petite mal IV ( heart and breathing risk!!) 7arada. |
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Clonazerpam |
petit mal + myoclonic |
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Clorazepate |
Complex partial + extra |
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Hydantoin |
Phenytoin (common) -> stron epilepsy tonic clonic ( dampening effect) block Na+ channels carbamazepine + valproate ( less strong epilepsies) |
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Phenytoin |
Tonic clonic, weak acid, slow absorption, 90% b cant take if you have petite mal bile then urine teratogenic not for liver sick people |
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ethotoin |
is safer but less active than phenytoin |
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Lamotrigine |
Abscence for children Na+ blocker |
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Topiramate |
on everything gaba,sodium,calcium partial tonic clonic for children
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if it ends in mide |
it blocks Calcium against PDS abscence
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Carbamazepine |
Tegretol grand mal more inhibition on Na+ just like phenytoin more metabolism on warfarin+phenytooin+steroid(cyp450) Adensoine active because of it |
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Valporic acid |
petit mal ( grand mal too) SIDE EFFECTS: teratogenic+phenobarbital higher
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status epileticus |
doesnt have to epilepsic shake non stop!! but it can be without spasm DAYE333 VALIUM IV,phenytoin,phenobarbital all because of trauma o |
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Gabapentin |
Analog for gaba |
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MK-801 |
Against NMDA (during depolarization without Mg) but people stopped feeling because there is NMDA in the spinal cord |
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Zonisamide |
Na blocker like phenytoin(non active channel tho) increase recovery time T type too dopamine + serotonin increase allosteric on gaba |
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Pregabalin |
more useful than gabapentin barely enters BBB alpha-2-delta(calcium)->less glutamate less sub P dose dependent
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Tigabaine |
GAT-1 inhibitor |
