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11 Cards in this Set
- Front
- Back
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Pyrimethamine |
Toxoplasmosis |
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Suramin and melarsoprol |
Trypanosoma brucei |
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Nifurtimox |
T. cruzi |
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Sodium stibogluconate |
Leishmaniasis |
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Chloroquine MOA |
Blocks detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia. |
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Chloroquine clinical use |
Treatment of plasmodial species other than P. falciparum (frequency of resistance in P. falciparum is too high) |
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Chloroquine resistance mechanism |
membrane pump that dec intracellular concentration of drug |
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P. falciparum treatment |
artemether/lumefantrine or atovaquone/proguanil. |
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Life-threatening malaria treatment |
Quinidine in U.S. (quinine elsewhere) or artesunate |
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Chloroquine toxicity |
Retinopathy; pruritis (dark-skinned individuals especially) |
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Antihelminthic therapy |
Mebendazole, pyrantel pamoate, ivermectin, diethylcarbamazine, praziquantel; immobilize
Use praziquantel against flukes (trematodes) such as Schistosoma. |
