Anti Parkinson Drugs/pharm

Front 1

loss of cholinergic neurons in nucleus basalis of Maynert

Back 1

in Alzhemier's disease

Front 2

loss of striatal projection neurons

Back 2

huntington's disease

Front 3

loss of dopaminergic neurons in the substantia nigra

Back 3

parkinson's disease

Front 4

what four features charac parkinson's disease

Back 4

bradykinesia
muscular rigidity
resting tremor
impairment of postural balance

Front 5

what are the forst symptoms to appear in parkinson's diases

Back 5

rolling tremor of the hand and mask like face

Front 6

what is the rate limiting step in the dopamine synthesis

Back 6

conversion of tyrosine>L-DOPA by tyrosine hydroxylase

Front 7

what enzyme is abudant in brain

Back 7

DOPA decarboxylase: conv L DOPA to dopamine

Front 8

cytoplamic dopamine is degraded by

Back 8

MAO

Front 9

what receptors are lost in parkinson disease

Back 9

D2: found in substantia nigra

Front 10

by th time first symptoms appear +______%of neurons are lost

Back 10

70

Front 11

death___% of neurons are lost

Back 11

90

Front 12

dopamine action is

Back 12

inhibitory

Front 13

can dopamine cross BBBB

Back 13

nop

Front 14

inceased dopamine in the peripheral system causes

Back 14

nausea, vommiting, orthostatic hypotension

Front 15

what are the drugs that act as dopamine precursors

Back 15

levodopa
carbidopa

Front 16

inhibitors of dopamine metabolism is

Back 16

selegiline
rasagiline

Front 17

COMT inhibitors

Back 17

entacapone
tolcapone

Front 18

dopamine receptor agonists

Back 18

bromocriptine
apomorphine
pramipexole
ropinirole
rotigotine

Front 19

nondopamergic

Back 19

amantadine

Front 20

levodopa (L DOPA)

Back 20

readily crosses BBB

Front 21

L-Dopa side effcets in peripheral system are

Back 21

nausea, vommiting, cardiac arrthymias, hypotension

Front 22

what _%L-DOPA reaches CNS

Back 22

1-3%

Front 23

what is an inhibitor of DOPA decarboxylase

Back 23

carbidopa: does not cross BBB

Front 24

how is carbidopa benefoicial

Back 24

prevents the peripheral side effects as it prevents the conversion of L-DOPA to dopamine in peripheral system

Front 25

L-DOPA is always adminstered with

Back 25

carbidopa

Front 26

brown saliva and urine
hypotension
anorexia
nausea'
vomitting
mydriasis

Back 26

side effcets of L-DOPA and carbidopa

Front 27

visual and
hallunication
dyskineasea
mood changes, depression, psychosis
anxiety

Back 27

all CNS side effects LDOPA and carbidopa

Front 28

vitamin pyridoxine (b6)

Back 28

increases peripheral breakdown of L-DOPA

Front 29

can excerbate symptoms in psychotic patients

Back 29

L-DOPA and CArbidopa

Front 30

can increases intraocular pressure in glaucoma patients

Back 30

L-DOPA and CArbidopa

Front 31

can cause cardiac arrthymias

Back 31

L-DOPA and CArbidopa

Front 32

antipsychotic drugs

Back 32

can potentially block dopamine R's

Front 33

selegiline and rasadiline are

Back 33

MAO-B inhibitors not MAO-A

Front 34

severe hypertension

Back 34

selegiline

Front 35

selegiline is metabolized to

Back 35

methamphetamine and amphetamine

Front 36

not metabolized to amphetamine like substances

Back 36

rasagiline

Front 37

5X more potent than selegilien

Back 37

rasagiline

Front 38

irreversible non selective inhibitor of brain MAO-B

Back 38

rasagiline

Front 39

fluminating hepatic necrosis

Back 39

COMT inhibitors(tolcapone only)

Front 40

extensively bound to albumin

Back 40

COMT inhibitors(tolcapone and entacapone)

Front 41

COMT that is not hepatotoxic

Back 41

entacapone

Front 42

what are the adverse effects of COMT inhibitors(tolcapoen and entacapone)

Back 42

diarrhea, postural hypotension, nausea, anorexia, dyskinesias, hallucinations, sleep disorders.

Front 43

which COMT inhibitor has greater duration of acti0n

Back 43

tolcapone

Front 44

which COMT can penetrate BBB

Back 44

tolcapone and inhibit COMT in brain

Front 45

ergot dopamine agonists

Back 45

bromocriptine

Front 46

bromocriptine is contraindicated in which gp of people

Back 46

history of MI
peripheral vascular disease
peptic ulcers
psyc illness

Front 47

peptic ulcers so what is CI

Back 47

bromocriptine

Front 48

what are the non ergot dopamine agonists

Back 48

apomorphine
pramipexole
ropinirole
rotigotine

Front 49

which ones do not compete for BBBB

Back 49

non ergot dopamine agonists

Front 50

available in trandermal formulations

Back 50

rotigotine

Front 51

inhibitors of CYP1A2

Back 51

ropinirole(non ergot dopamine agonists)
D3R>D2R.

Front 52

depends on good renal function for elimination

Back 52

pramipexole

Front 53

used for acute management of Off phenomenon

Back 53

apomorphine

Front 54

powerful emetic drug and is a opiod but do not bind to opiod receptors

Back 54

apomorphine

Front 55

which one play only adjuvant role in aniparkinson therapy

Back 55

antimuscranics

Front 56

pyloric stenosis

Back 56

CI is antimuscranics

Front 57

antimiscranics are CI in

Back 57

glaucoma
prostatic hyperplasia
pyloric stenosis

Front 58

increases release of dopamine, blocks cholinergic receptors and inhibits NMDA glutamate receptors

Back 58

amantadine

Front 59

little effect on tremor but more effective than anticholinergics against rigity and bradtkinesia

Back 59

amantadine

Front 60

what other porposes is amantatide used

Back 60

ANTI VITAL AGENT FOR INFLUENZA A

Front 61

in high doses cause acute toxic psychosis

Back 61

amantadine

Front 62

restlessness,
agatation
confusion
hallucinations
orthostatic hypotension
urinary retyension
peropheral edema
dry mouth

Back 62

all are the side effects of amantadine

Front 63

mood changes
dryness of mouth
vision problems
pupillary dilation
hallucinatins
urinary retension
sinus tachycardia
constipation
are all side effects of

Back 63

antimuscranics

Front 64

has largely repalced tolcapone

Back 64

entacapone

Front 65

forms of toxic metabolite amphetamine (can lead to insomnia and confusion in elderly)

Back 65

selegiline

Front 66

treats L-DOPA induced dyskinesias in late stages

Back 66

amantadine