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36 Cards in this Set

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Antimetabolites
CCS Drugs:
Methotrexate
5-Fluorouracil
Cytarabine
Azathioprine/Mercaptopurine
Capecitabine
Alkylating Agents
CCNS Drugs:
Cyclophosphamide
Carmustine
Temozolamide
Cisplatin
Natural Products
CCS (M-phase) Drugs:
Vincristine
Vinblastine
Etoposide
Topotecan
Paclitaxel
Hormones
Tamoxfen
Anastrozole
Fulvestrant
Flutamide
Finasteride
Leuprolide
Cytotoxic Antibiotics
Intercalating Agents:
Daunorubicin
Doxorubicin
Dactinomycin
Bleomycin
Monoclonal Antibodies
Rituximab
Trastuzumab
Others
Asparaginase
Imatinib Mesylate
Hydroxyurea
Methotrexate
MoA: competitive and reversible DHRF inhibitor;
RoA: oral, IV, intrathecal;
Clinical Uses: solid tumors, immunosuppressive in graft rejection control, RA;
Antidote: Leucovorin (aka-folinic acid, for cancer tx.); Folate (for RA tx);
AE: nephrotoxicity;
CI: PREGNANCY
5-Fluorouracil
MoA: interferes with RNA function and inhibits DNA synthesis;
Clinical Uses: cancers of bladder, prostate, pancreas, oropharnygeal, colon, and kidney; (5-FU + leucovorin is used for colon cancer);
Capecitabine
MoA: inhibits thymidylate synthase; oral prodrug converted to 5-FU;
Clinical Uses: used with paclitaxel and doxorubicin in the tx of resistant colorectal or metastatic breast cancers
Cytarabine
MoA: blocks elongation of DNA synthesis;
Clinical Uses: DOC for AML;
AE: Neurotoxicity
Azathioprine/Mercaptopurine
MoA: inhibits PRPP synthetase blocking de novo purine synthesis;
Clinical Uses: immunosuppressants, RA, antimalignants;
AE: bone marrow suppression, leukopenia
Cyclophosphamide
MoA: prodrug converted in the liver; affects DNA and RNA synthesis;
RoA: oral, IV;
Clinical Uses: leukemia, solid tumors, NHL, ovarian cancer, neuroblastoma, immunosuppressive to prevent graft rejection, SLE;
Other: metabolized to mustard (nephrotoxic causing SIADH, antidote: demeclocycline) and acrolein (causes hemorrhagic cystitis, antidote: mesna)
Carmustine
Clinical Uses: CNS cancers since it can cross the BBB
Temozolamide
Clinical Uses: tx of malignant gliomas since it can also cross the BBB
Cisplatin
MoA: inhibits replication and transcription;
Clinical Uses: urogenital cancers;
RoA: IV or rapid injection (needle must not contain aluminum!!);
Antidote: amifostine;
AE: nephrotoxicity and ototoxicity
Vincristine
MoA: binds to tubulin and blocks assembly of microtubules;
Clinical Uses: pediatric leukemias, solid tumors, Hodgkins, rhabdomyosarcoma, lymphomas, neuroblastomas;
AE: peripheral neuropathy (christ my nerves!)
Vinblastine
MoA: bind to tubulin and prevents assembly of microtubules;
Clinical Uses: Hodgkins, testicular carcinoma;
AE: reversible myelosuppression, leukopenia, alopecia (blast my bones!)
Etoposide
MoA: Topo 2 complex inhibitor;
Clinical Uses: first time and metastatic testicular cancer;
AE: dose limiting leukopenia;
CAUSES AML!!!
Topotecan
MoA: Topo 1 complex inhibitor;
AE: dose limiting neutropenia
Paclitaxel
MoA: inhibits microtubule DISassembly;
Clinical Uses: ovarian & breast cancer; lung, esophageal, bladder, head & neck cancer;
AE: HS rxns, neutropenia, cardiac conduction defects
Tamoxifen
MoA: selective estrogen receptor modulator (SERM), blocks binding of estrogen to its receptor in breast cancer;
Clinical Uses: tx and prophylaxis of breast cancer; infertility, gynecomastia;
AE: hot flashes, vaginal bleeding, hypercalemia, peripheral edema
Anastrozole
MoA: aromatase inhibitor, prevents estrogen synthesis;
Clinical Uses: breast cancer
Fulvestrant
MoA: estrogen receptor antagonist;
Clinical Uses: metastatic breast cancer in post-menopausal women
Flutamide
MoA: androgen receptor antagonist;
Clinical Uses: prostate cancer
Finasteride
MoA: inhibits 5-alpha-reductase, which inhibits the synthesis of testosterone to DHT;
Clinical Uses: BPH and male pattern baldness
Leuprolide
MoA: GNRH receptor agonist;
Clinical Uses: used in hormone responsive cancers such as prostate and breast cancer; endometriosis
Daunorubicin
MoA: Topo 2 complex inhibitor;
Clinical Uses: Leukemia, NHL;
AE: cardio toxicity and red urine
Doxorubicin
MoA: Topo 2 complex inhibitor;
Clinical Uses: solid tumors of the breast, endometrium, testes, and lung; ABVD in Hodgkin's; CHOP in NHL; osteogenic and Ewing's sarcoma, soft tissue sarcoma; metastatic carcinoma of the thryoid;
Antidote: dexrazoxane (FE chelator);
AE: cardio toxicity
Dactinomycin
MoA: binds DNA helix and prevents transcription of DNA by RNA polymerase;
Clinical Uses: rhabdomyosarcoma, Wilm's tumor, Ewing's tumor, Kaposi's sarcoma;
RoA: IV;
AE: hematopoietic suppression, pancytopenia-dose limiting property
Bleomycin
MoA: inhibits cell cycle at G2; blows DNA apart;
Clinical Uses: testicular cancers; squamous cell carcinomas of head, neck, and lungs; lymphomas;
AE: pulmonary toxicity and pulmonary fibrosis
Rituximab
MoA: chimeric anti-CD20 monoclonal antibody that binds to the CD20 antigen on follicular B cells;
Clinical Uses: Non Hodgkins Lymphoma (NHL)
Trastuzumab
MoA: recombinant human monocolonal antibody that binds EGF-R2;
Clinical Uses: breast cancer (HER2/NEU);
AE: cardio toxicity
Asparaginase
MoA: deprives cancer cells of asparagine needed for protein synthesis, leads to cell death by activation of apoptosis;
RoA: IV
Clinical Uses: ALL;
Toxicity: alopecia; HS rxns; toxic to CNS at high doses; clotting abnormalities
Imatinib Mesylate
MoA: inhibits the BCR-ABL tyrosine kinase translocation of the Philadelphia chromosome;
Clinical Uses: CML
Hyrdoxyurea
MoA: inhibits ribonucleotide reductase;
Clinical Uses: myeloproliferative disorders: CML, PV, ET, etc.