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29 Cards in this Set
- Front
- Back
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oncovin aka vincristine MOA =
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inhibits mitosis (originates from vinka alkaloid)
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Oncovin indications:
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acute leukemia; also the 'O' in CHOP combination therapy
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Side effects of Oncovin include:
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neurotoxicity and vesicant
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5-flurouracil (5-FU) MOA =
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antimetabolite; incorporates into RNA, inhibits DNA synthesis
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Indications of 5-flurouracil
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head/neck, esophageal, breast, pancreas, colon cancers. AND PRE-malignant SKIN Lesions
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Side effects of 5-flurouracil
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mucositis, diahrrea, myelosupression, skin dryness, nausea/vomiting
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Taxol MOA=
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arrests cell cycle at G2 and M phase
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Taxol indications:
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head/neck, breast, lung, ovarian cancer
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Taxol side effects:
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hypersensitivity, sensory neuropathy, myalgia, arthralgia, myelosupression
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bleomycin (Blenoxane) MOA =
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antitumor antibiotic. Breakage of single and double stranded DNA by binding to DNA and inhibiting DNA synthesis
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bleomycin (Blenoxane) indications:
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testis and cervical cancer; Hodgkin's disease. Not used as mono-therapy. Used in ABVD Hodgkin's disease regimin. represents 'B'
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bleomycin (Blenoxane) side effects:
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fever, thrombophlebolitis, acute anaphylaptic rxns: *Pulmonary toxicity, interstitial pneumonitis, fibrosis, cardio respiratory collapse in patients with lymphoma
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cyclophosphamide (Cytoxan) MOA=
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alkylating agent; disrupts DNA; commonly used in combination 'C' in CHOP, can cross BBB
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cyclophosphamide (Cytoxan) indications:
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Hodgkin's disease, lymphoma; breast, ovary and lung cancer
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cyclophosphamide (Cytoxan) AE:
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nausea/vomiting, alopecia, myelosupression
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Avastin/bevacizumab MOA:
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anti-angiogenesis; inhibits development of blood vessels
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Avastin/bevacizumab indications:
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solid tumors; used in combination for brain cancer
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Avastin/bevacizumab AE=
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HTN, diarrhea, impaired wound healing, infusion rxns
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Sutent/sunitinib oral MOA=
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angiogenesis inhibitor
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Sutent/sunitinib oral Indications=
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advanced kidney cancer, GIST, stomach, bowel, esophagus cancer
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Sutent/sunitinib oral AE=
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QT INTERVAL PROLONGATION, skin discoloration, rash, diarhhea, myelosupression
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methotrexate, IV, IT, PO MOA=
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folic acid anatagonist; damages cell @ S phase; inhibits dihydrofolate reductase, inhibits DNA synthesis
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methotrexate indications:
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RHUMATOID ARTHRITIS (oral), acute lymphocitic leukemia, breast, head/neck and lung cancer
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tamoxifen MOA
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anti-estrogen; blocks estrogen receptor in cancer cells
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tamoxifen indications:
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breast cancer
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tamoxifen AE:
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weight gain, hot flashes, abnormal menstrual period, nausea/vomiting
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leuprolide MOA=
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luteinizing hormone (LH) and follicle stimulating hormone (FSH) is reduced which leads to a reduction in Testosterone production
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leuprolide indications:
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prostate cancer
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leuprolide AE=
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hotflashes, depression, headache
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