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10 Cards in this Set
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Sirolimus |
Sirolimus inhibits T-lymphocyte activation and proliferation that occurs secondary to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation.
Specifically, sirolimus inhibits T-cell proliferation by binding to immunomodulin FK-BP WHICH INHIBITS specific serine-threonine kinase (mTOR), which is necessary for cell cycle progression. |
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What is speciality of sirolimus when compared to tacrolimus? |
Sirolimus is not nephrotoxic |
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Which are the calcineurin inhibitors? |
Tacrolimus Cyclosporine |
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Intercalating into DNA |
Danarubacin Doxorubicin Main side FX : cardiotoxic |
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Which are the calcineurin inhibitors? |
Cyclosporine and Tacrolimus MOA : Inhibit calcineurin-mediated transcription of the IL-2 gene and subsequently reduce T-cell activation. Side FX: nephrotoxicity sirolimus synergistically enhances cyclosporine-induced nephrotoxicity. |
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Bortezumib |
Used in multiple myeloma Inhibits proteosome 26s leading to accumulation of pro apoptotic proteins |
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Rituximab |
Chimeric antibody against CD20 .....depletes B cell |
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Mycophenolate |
inhibits purine syn ( IMP dehydrogenase) Affects b and t cell |
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Etoposide |
Topoisomerase 2 inhibitor
ca Testicular caSmall cell lung cancer Small cell lung cancer |
Syn podophyllotoxin |
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Topoisomerase I inhibitor |
Topotecan Irinotecan |
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