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4 Cards in this Set
- Front
- Back
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Alkylating Agents
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MOA: Cross-links two DNA Strands; are metabolized by the liver to form highly reactive electrophiles
Classic Drug: Cyclophosphamide --- gets activated to become phosphoramides/acrolein (bladder toxicity) -Indications: Solid and Hematologic Tumors, BMT, immunosuppression |
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S-Phase Specific Anti-Metabolites
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Classic Drug: Methotrexate
MOA: Competitive inhibitor of DHFR; blocks folic acid synthesis Indications: solid/hematologic tumors- ALL, breast/lung/neck, sarcomas Dose-dependent toxicity, myelosuppression, N/V, mucositis, hepatotoxic, neurotoxic, nephrotoxic |
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Anti-Metabolites: Plant Alkaloids
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Classic Drug: Vincristine
MOA: Blocks microtubule synthesis (mitotic spindle poison) Indications: ALL, NHL, SCLC, Sarcoma, Hodgkin's, myeloma Adverse effects: Neurotoxic, constipation |
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Anti-tumor Antibiotics
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Classic Drug: Anthracyclins "the rubicins"--doxorubicin
MOA: Intercalates in b/n DNA base pairs to generate free radicals Indications: Solid/hematologic tumors Lifetime dose: 550 mg-- CARDIOTOXIC, RED URINE |
