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14 Cards in this Set

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Atropin
Tertiary amine / Anti-muscarinic
Crosses BBB
Used to reverse Anti-muscarinic poisoning
Long lasting myadrisis (pupil dilation)
Together with diphenoxylate acts as an antidiarrheal
Scopolamine
Tertiary amine
It crosses BBB
Helps control seasickness
Small amount has small sedating effect
Large amount it causes mild euphoria
Tropicamide
Anti-muscarinic
Short acting myadriatic agent
Tertiary (crosses BBB)
May rise intraocular pressure
Tolterodine
Anti-muscarinic
Drug of choice to manage an overactive bladder with symptoms of increased urgency or frequency
Oxybutynin
3 amine Anti muscarinic
Together with Tolterodine help control an overactive bladder with increased urgency or frequency
May increase tone in bladder muscle
Helps close sphincter
Ipratropium
Quaternary amine - anti-muscarinic
Used to treat COPD
Not effective for asthma
Propantheline
Quaternary amine - anti-muscarinic
Orally administered / very low cardiovascular activity, short duration 6 h
Competitive mAChR antagonist
non-obstructive irritable bowel syndrome, other GI disturbances
Causes excessive sweating
Nicotine
Non depolarizing ganglionic blocker
Used for smoking cessation
Stimulation of adrenal medulla, releases NE from chromaffin cells
Hexamethonium
Non-depolarizing ganglionic blocker
The first anti-hypersensitive drug
Used in research
Poor absorption
Autonomic side effects
Tetraethylammonium
Non-depolarizing competitive autonomic ganglia nAChR antagonist
Ganglionic blocker
Research Only
Poor absorption
autonomic side effects
Methacholine
Muscarinic agonist
Ch3 - ACh
Used to diagnose bronchial hypersensitivity and asthmatic conditions
At high doses can lead to cardiac arrest
Choline ester
Carbachol
Muscarinic agonist
ACh - NH2
Last line drug for wide-angle glaucoma
Has significant nicotinic activity at Nicotinic receptors
Bethanechol
Direct muscarinic agonist
ACh - NH2 - CH3
Used for post-partum / post-operatively to enhance normal function of GI tract and bladder; promotes intestinal motility and tone
Xerostomia
Little effect on CV system
Pilocarpine
Miotic agent for wide angle glaucoma (contracts the ciliary muscle and opens the canal of schlemm)
Cholinergic agonist