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19 Cards in this Set
- Front
- Back
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MOA of Penicillin
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Binds PBPs to block transpeptidase cross-linking of peptidoglycan w/o penicillinase resistance
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Drug which acts by binding PBPs to block transpeptidase cross-linking of peptidoglycan w/o penicillinase resistance
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Penicillin
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Toxicity of penicillin
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Allergic rxn
Hemolytic anemia |
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Antimicrobial which can cause allergic rxn and/or hemolytic anemia
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Penicillin
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Unique toxicity of methicillin
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Interstitial nephritis
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MOA of Methicillin (& nafcillin, dicloxacillin)
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Binding PBPs to block transpeptidase cross-linking of peptidoglycan WITH penicillinase resistance
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Drugs which act by binding PBPs to block transpeptidase cross-linking of peptidoglycan WITH penicillinase resistance
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Methicillin (& nafcillin, dicloxacillin)
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MOA of Ampicillin, Amoxicillin
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Binding PBPs to block transpeptidase cross-linking of peptidoglycan with wide spectrum but penicillinase sensitive
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Toxicity of ampicillin/amoxicillin
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Pseudomembranous colitis
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Antipsuedomonals
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Ticarcillin
Carbenicillin Piperacillin |
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Beta-lactamase inhibitors
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Clavulanic Acid
Sulbactam Tazobactam |
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Beta-lactams w/ less susceptibility to penicillinases
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Cephalosporins
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Cephalosporin toxicity
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1. Vitamin K Deficiency
2. Allergic (w/ penicillins) 3. Nephrotoxic (w/ AGs) 4. Disulfram-like (cefamandole) |
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MOA of Aztreonam
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Binds PBP3 to inhibit cell wall synthesis
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MOA of Vancomycin
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Inhibits mucopeptide formation by binding D-ala-D-ala portion of cell wall
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Acquired resistance to Vancomycin?
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D-ala-D-ala change to D-ala-D-lac
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Toxicity of Vancomycin
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"Red Man Syndrome"
Nephrotoxic Ototoxic Thrombophlebitis |
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Toxicity of carbapenems
(Imipenem/cilastatin, meropenem) |
Seizures
GI distress skin rash |
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Fxn of cilastatin when combined with imipenem
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Inhibits renal dehydropeptidase I to decrease inactivation of the drug.
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