Anti Microbial - Nucleic Acid Synthesis Inhibitors

Front 1

Two major mechanisms for preventing Nucleic acid synthesis in microbes?

Back 1

1) Inhibition of folic acid synthesis (without Folic acid, there will no Uracil conversion to Thymine, and no/reduced formation of Adenine and Guanine = decreased DNA/RNA production)
2) Inhibition of topoisomerase II and IV.

Front 2

This group of drugs are involved in inhibiting Topoisomerase II and IV.

Back 2

Fluoroquinolones

Front 3

List the fluoroquinolones (6)
Name the one quinolone.

Back 3

Fluoroquinolones:
1) Norfloxacin
2) Levofloxacin
3) Ciprofloxacin
4) Ofloxacin
5) Gemifloxacin
6) Moxifloxacin

Quinolone:
Naldixic acid

Front 4

These enzymes are targets for inhibition when your goal is to inhibit nucleic acid synthesis in microbes.

Back 4

Dihydropterate synthetase
Dihydrofollate reductase

Front 5

MOA of Sulfonamides?

Back 5

Competitively inhibit Dihydropterate synthetase.

Front 6

Enzyme found in bacteria but not humans, that allows for the formation of folic acid.

Back 6

Dihydropterate synthetase

Front 7

MOA of Trimethoprim?

Back 7

Inhibits dihydrofollate reductase.

Front 8

MOA of Pyrimethamine?

Back 8

Inhibition of dihydrofollate reductase.

Front 9

Name the two common combination therapies used in nucleic acid synthesis inhibition.

Back 9

1) Trimethoprim-Sulfamethoxazole
2) Pyrimethamine-Sulfadiazine