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38 Cards in this Set
- Front
- Back
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What drug has major contra-ind in pt's w/ dec renal function?
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thiazides
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What is MOA of methyldopa?
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converted to methylnorepi and acts as false NT to stimulate alpha-2 to dec symp
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What CNS drug may unmask or exacerbate depression?
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methyldopa
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What is MOA of clonidine?
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alpha-2 agonist, can stimulate alpha-1 and inc BP
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What is first anti-HTN to be a patch?
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clonidine
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What are the drug interactions of clonidine?
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Beta blockers inc w/d syn, TCA block hypotensive effects of clonidine
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What is MOA of guanfacine?
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alpha-2 agonist
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What are beta-1 selective drugs?
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atenolol, acebutolol, metoprolol, bisoprolol, betaxolol
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What nonselective beta blockers have some sympathomimetic actions?
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penbutolol, cartelol
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What is a vasodilatry beta blocking drug?
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celiprolol
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What are 3 results of blocking beta R?
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dec CO, dec symp outflow, inhibit renin release (b1)
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What nonselective beta blocker is highly ptn bound and subject to 1st pass metabolism?
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propranolol (prototype)
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What nonselective beta blocker has long half life?
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nadolol
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What nonselective beta blocker can be used to tx glaucoma?
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timolol
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What are the mixed alpha1 and beta 1 blockers?
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labetolol, carvediol
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What alpha antagonist is less alpha-1 selective and highly ptn bound?
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prazosin
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What alpha antagonist has high bioavailability, longer duration of action and dec postural hypotension?
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terazosin
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What alpha antagonist is highly ptn bound but has long half life and dec first dose effect?
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doxazosin
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SE of alpha antagonists are due to what?
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excessive vasodilation
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What is first dose effect of alpha antag?
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sudden onset of dizziness, palpitations, syncope; due to to impaired venous retrn and vasodilation
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What anti-HTN can be used to tx BPH?
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alpha antag b/c relax smooth muscle
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What is MOA of reserpine?
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depletes NE by preventing storage in granules, inhibits amine tport of granules
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What is major contra-ind of reserpine?
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do not use in depressed pts
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What are drug interactions of reserpine?
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MAOI, TCA b/c there will be builup of norepi therby negating reserpine action
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What is MOA of guanethedine?
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inhibits AP of NE, inhibits NE reuptake, displacement of NE
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What anti-HTN is reserved for severe or refractory HTN?
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guanethedine
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What are the vasodilators?
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hydralazine, minodoxil
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What drugs are never used as monotherapy?
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vasodilators
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What vasodilator is reserved for severe or refractory HTN and can be used for male pattern baldness?
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minodoxil
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What is suffix of ACEI?
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-opril
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What type of inhibition are ACEI?
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competitive
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What drug must be avoided w/ ACEI?
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K-sparing diuretics
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What are SE of ACEI?
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cough, angioedema, hypotension, taste disturbances
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What are ATII antagonists?
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losartan, valsartan
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What is renin inhbitor?
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aliskiren
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What are the Ca++ channel blockers?
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verapamil, diltiazam, and -ipine's
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What Ca++ blocker has greatest effect on cardiac conduction?
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verapamil
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What are 3 advantages of Ca++ antag over other anti-HTN?
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do not alter lipids, maintain/inc GFR, do not interfere w/ exercise
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