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10 Cards in this Set
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leukotrine effects:
VSM 1 or 2 NVSM 3 constriction and 4 of other NVSM other effects: 5 effects 6 vascular 7 inhibit 8 8 secretions |
1 vasoconstriction
2 vasodilation 3 bronchial 4 contraction 5 inflammatory 6 increased 7 permeability 8 gastric acid |
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Histamine can be released from 1 cells upon 2 antigenic stimulation:
*causes 1 cell 3 *4 & similar agents block this 3 * 2 cell 3 can be activated by other stimuli: -5 and other drugs -some 6 toxins -7 C3a & C5a as part of the complement cascade -8 stimuli and others |
1 mast
2 IgE 3 degranulation 4 cromolyn 5 morphine 6 bacterial 7 anaphylatoxins 8 physical |
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Effects of histamine 1 activation:
Allergic Rx -1, 2, 3 Get 4 in skin & 5 membranes -6,7,8,9,10 11 12 endings -in 13 tissue causing 14 -in 15 causing 16 -in 17 causing 18 if large amnts are released in systemic circulation get 19 shock |
1 dermititis
2 rhinitis 3 conjunctivitis 4 vasodilation 5 mucous 6 redness 7 warmth 8 congestion 9 edema 10 inflammation 11 stimulate 12 nerve 13 mucocutaneous 14 itching 15 lungs 16 cough 17 bronchial 18 constriction 19 anaphlyaxis 17 |
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H1 receptors antagonists = 1
Divided into 1st and 2nd generations *1st are 2 and cross 3 -cause 4 -can have 5 effects *anti 6 *anti 7 Are 8 9 of histamine |
1 antihistamines
2 lipophilic 3 BBB 4 sedation 5 CNS 6 vertigo 7 nausea 8 COMPETITIVE 9 inhibitors |
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Side Effects
1st generation: * 1 -paradoxic CNS stim. kids & elderly *2 anticholinergic effects -C=3 -DM=4 -DE=5 -UR=6 |
1 sedation
2 significant 3 constipation 4 dry mouth 5 dry eyes 6 urinary retention |
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leukotrine effects:
VSM 1 or 2 NVSM 3 constriction and 4 of other NVSM other effects: 5 effects 6 vascular 7 inhibit 8 8 secretions |
1 vasoconstriction
2 vasodilation 3 bronchial 4 contraction 5 inflammatory 6 increased 7 permeability 8 gastric acid |
|
|
Histamine can be released from 1 cells upon 2 antigenic stimulation:
*causes 1 cell 3 *4 & similar agents block this 3 * 2 cell 3 can be activated by other stimuli: -5 and other drugs -some 6 toxins -7 C3a & C5a as part of the complement cascade -8 stimuli and others |
1 mast
2 IgE 3 degranulation 4 cromolyn 5 morphine 6 bacterial 7 anaphylatoxins 8 physical |
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|
Effects of histamine 1 activation:
Allergic Rx -1, 2, 3 Get 4 in skin & 5 membranes -6,7,8,9,10 11 12 endings -in 13 tissue causing 14 -in 15 causing 16 -in 17 causing 18 if large amnts are released in systemic circulation get 19 shock |
1 dermititis
2 rhinitis 3 conjunctivitis 4 vasodilation 5 mucous 6 redness 7 warmth 8 congestion 9 edema 10 inflammation 11 stimulate 12 nerve 13 mucocutaneous 14 itching 15 lungs 16 cough 17 bronchial 18 constriction 19 anaphlyaxis 17 |
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H1 receptors antagonists = 1
Divided into 1st and 2nd generations *1st are 2 and cross 3 -cause 4 -can have 5 effects *anti 6 *anti 7 Are 8 9 of histamine |
1 antihistamines
2 lipophilic 3 BBB 4 sedation 5 CNS 6 vertigo 7 nausea 8 COMPETITIVE 9 inhibitors |
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Side Effects
1st generation: * 1 -paradoxic CNS stim. kids & elderly *2 anticholinergic effects -C=3 -DM=4 -DE=5 -UR=6 |
1 sedation
2 significant 3 constipation 4 dry mouth 5 dry eyes 6 urinary retention |
