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10 Cards in this Set

  • Front
  • Back
leukotrine effects:

VSM
1 or 2

NVSM
3 constriction and 4 of other
NVSM

other effects:
5 effects
6 vascular 7
inhibit 8 8 secretions
1 vasoconstriction
2 vasodilation

3 bronchial
4 contraction

5 inflammatory
6 increased
7 permeability
8 gastric acid
Histamine can be released from 1 cells upon 2 antigenic stimulation:
*causes 1 cell 3
*4 & similar agents block
this 3

* 2 cell 3 can be activated by other stimuli:
-5 and other drugs
-some 6 toxins
-7 C3a & C5a as part of the complement cascade
-8 stimuli and others
1 mast
2 IgE

3 degranulation
4 cromolyn

5 morphine
6 bacterial
7 anaphylatoxins
8 physical
Effects of histamine 1 activation:

Allergic Rx
-1, 2, 3

Get 4 in skin & 5 membranes
-6,7,8,9,10

11 12 endings
-in 13 tissue causing 14
-in 15 causing 16
-in 17 causing 18

if large amnts are released in systemic circulation get 19 shock
1 dermititis
2 rhinitis
3 conjunctivitis

4 vasodilation
5 mucous
6 redness
7 warmth
8 congestion
9 edema
10 inflammation

11 stimulate
12 nerve
13 mucocutaneous
14 itching
15 lungs
16 cough
17 bronchial
18 constriction

19 anaphlyaxis
17
H1 receptors antagonists = 1

Divided into 1st and 2nd generations
*1st are 2 and cross 3
-cause 4
-can have 5 effects
*anti 6
*anti 7

Are 8 9 of histamine
1 antihistamines
2 lipophilic
3 BBB
4 sedation
5 CNS
6 vertigo
7 nausea

8 COMPETITIVE
9 inhibitors
Side Effects
1st generation:
* 1
-paradoxic CNS stim.
kids & elderly
*2 anticholinergic effects
-C=3
-DM=4
-DE=5
-UR=6
1 sedation
2 significant
3 constipation
4 dry mouth
5 dry eyes
6 urinary retention
leukotrine effects:

VSM
1 or 2

NVSM
3 constriction and 4 of other
NVSM

other effects:
5 effects
6 vascular 7
inhibit 8 8 secretions
1 vasoconstriction
2 vasodilation

3 bronchial
4 contraction

5 inflammatory
6 increased
7 permeability
8 gastric acid
Histamine can be released from 1 cells upon 2 antigenic stimulation:
*causes 1 cell 3
*4 & similar agents block
this 3

* 2 cell 3 can be activated by other stimuli:
-5 and other drugs
-some 6 toxins
-7 C3a & C5a as part of the complement cascade
-8 stimuli and others
1 mast
2 IgE

3 degranulation
4 cromolyn

5 morphine
6 bacterial
7 anaphylatoxins
8 physical
Effects of histamine 1 activation:

Allergic Rx
-1, 2, 3

Get 4 in skin & 5 membranes
-6,7,8,9,10

11 12 endings
-in 13 tissue causing 14
-in 15 causing 16
-in 17 causing 18

if large amnts are released in systemic circulation get 19 shock
1 dermititis
2 rhinitis
3 conjunctivitis

4 vasodilation
5 mucous
6 redness
7 warmth
8 congestion
9 edema
10 inflammation

11 stimulate
12 nerve
13 mucocutaneous
14 itching
15 lungs
16 cough
17 bronchial
18 constriction

19 anaphlyaxis
17
H1 receptors antagonists = 1

Divided into 1st and 2nd generations
*1st are 2 and cross 3
-cause 4
-can have 5 effects
*anti 6
*anti 7

Are 8 9 of histamine
1 antihistamines
2 lipophilic
3 BBB
4 sedation
5 CNS
6 vertigo
7 nausea

8 COMPETITIVE
9 inhibitors
Side Effects
1st generation:
* 1
-paradoxic CNS stim.
kids & elderly
*2 anticholinergic effects
-C=3
-DM=4
-DE=5
-UR=6
1 sedation
2 significant
3 constipation
4 dry mouth
5 dry eyes
6 urinary retention